Liposomes containing active agents

Details Liposomes containing active agents Liposomes containing active agents

1998-10-19

2000-11-07

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 121, 424 9321, 424 951, 424 943, 935 54, A61K 9127, A61K 9133

Patent

active

061433217

ABSTRACT:
Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.

REFERENCES:
patent: 5023086 (1991-06-01), Wallach
patent: 5755788 (1998-05-01), Strauss
patent: 5827533 (1998-10-01), Needham
Devlin, B. P. et al., A Kinetic Study of the Polyelectrolyte-Induced Reorganization of Lipid Bilayers, Am. Chem. Soc. Div. Polym. Chem. vol. 28, No. 2, (1987), pp. 50-51.
Hristova, K. et al. Effect of Bilayer Composition On the Phase Behavior Liposomal Suspensions Containing Poly(ethylene glycol) Lipids, Macromolecules, vol. 28, No. 23 (1995) pp. 7693-7699.
International Search Report for corresponding International Application No. PCT/US99/12964.

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