Liposomes containing a cisplatin compound

Details Liposomes containing a cisplatin compound Liposomes containing a cisplatin compound

1997-08-22

1999-08-31

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, A61K 9127

Patent

active

059451220

ABSTRACT:
A liposome composition containing an entrapped cisplatin compound is described. The liposomes have a surface coating of hydrophilic polymer chains on inner and outer surfaces and an entrapped cisplatin compound. The compound is entrapped with substantially greater retention in the liposomes, when compared to liposomes lacking the polymer coating. A method of preparing the composition is also described.

REFERENCES:
patent: 5178876 (1993-01-01), Khokhar et al.
patent: 5252336 (1993-10-01), Iga
PCT/US97/14541 International Search Report.
Lu, J.F. et al., "A Study of Interaction of Cisplatin and Its Analogues with Phospholipid of Erythrocyte Membrane," Journal of Chinese Pharmaceutical Sciences. 4:(03) 136-143 (1995).
Potkul, R.K. et al., "Toxicities in Rats with Free Versus Liposomal Encapsulated Cisplatin," Am J Obstet Gynecol. 164:(02) 652-658 (1991).
Prestayko, A.W., "Cisplatin and Analogues: A New Class of Anticancer Drugs," Cancer and Chemo. 3 Crooke, Stanley (Ed) and Prestayko, Archie (Ed), Academic Press NY, pp. 133-154 (1981).
Steerenberg, P.A. et al., "Liposomes as a Drug Carrier System for cis-Diamminedichloroplatinum (II). I. Binding Capacity, Stability and Tumor Cell Growth Inhibition In Vitro," International Journal of Pharmaceutics. 40: 51-62 (1987).
Steerenberg, P.A. et al., "Liposomes as Drug Carrier System for cis-Diamminedichloroplatinum(II)," Cancer Chemother. Pharmacol. 21: 299-307 (1988).
Sur, B. et al., "Effect of Liposomal Encapsulation of cis-Platinum Diamminodichloride in the Treatment of Ehrlich Ascites Carcinoma," Oncology. 40: 372-376 (1983).
Taylor, K.D. et al., "Pressure Tuning Infrared Spectroscopic Study of Cisplatin-Induced Structural Changes in a Phosphatidylserine Model Membrane," British Journal of Cancer. 72:1400-1405 (1995).
Weiss, R.B. and Christian, M.C., "New Cisplatin Analogue in Development," Drugs. 46:(03) 360-377 (1993).
Yatvin, M.B. et al., "Selective Delivery of Liposome-Associated cis-Dichlorodiammineplatinum(II) by Heat and Its Influence on Tumor Drug Uptake and Growth," Cancer Research. 41: 1602-1607 (1981).
Chen, B.W. et al., "Fluorescence Study on The Interaction Between Cisplatin and Erythrocyte Membrane Proteins," Journal of Chinese Pharmaceutical Sciences. 4:(03) (1995).
Freise, W.H. et al., "Pharmacokinetics of Liposome Encapsulated Cisplatin in Rats," Arch. Int. Pharmacodyn. 258: 180-192 (1982).
Gondal, J.A. et al., "Comparative Pharmacological, Toxicological and Antitumoral Evalutation of Free and Lipsome-Encapsulated Cisplatin in Rodents," Eur J Cancer. 29A:(11) 1536-1542 (1993).
Iga, K. et al., "Membrane Modification by Negatively Charged Stearyl-Polyoxyethylene Derivatives for Thermosensitive Liposomes: Reduced Liposomal Aggregation and Avoidance of Reticuloendothelial System Uptake," Journal of Drug Targeting. 2: 259-267 (1994).
Kaledin, V.I. et al., "Intralymphatic Administration of Liposome-Encapsulated Drugs to Mice: Possibility for Suppression of the Growth of Tumor Metastases in the Lymph Nodes," JNCI. 66:(05) 881-887 (1981).
Li, C. et al., "Formation and Characterization of Cisplatin-Loaded Poly(benzyll-glutamate) Microspheres for Chemoembolization," Pharmaceutical Research. 11:(12) 1792-1799 (1994).

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