Liposomes as contrast agents for ultrasonic imaging and apparatu

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent

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A61K 4900

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055714978

ABSTRACT:
Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.

REFERENCES:
patent: 3532500 (1970-10-01), Priest et al.
patent: 3873564 (1975-03-01), Schneider et al.
patent: 4089801 (1978-05-01), Schneider
patent: 4162282 (1979-07-01), Fulwyler et al.
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4224179 (1980-09-01), Schneider
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4310505 (1982-01-01), Baldeschwieler et al.
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4315514 (1982-02-01), Drewes et al.
patent: 4331654 (1982-05-01), Morris
patent: 4344929 (1982-08-01), Bonsen et al.
patent: 4426330 (1984-01-01), Sears
patent: 4428924 (1984-01-01), Millington
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4533254 (1985-08-01), Cook et al.
patent: 4534899 (1985-08-01), Sears
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4569836 (1986-02-01), Gordon
patent: 4572203 (1986-02-01), Feinstein
patent: 4586512 (1986-05-01), Do-huu et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4615879 (1986-10-01), Runge et al.
patent: 4620546 (1986-11-01), Aida et al.
patent: 4646756 (1987-03-01), Watmough et al.
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4658828 (1987-04-01), Dory
patent: 4675310 (1987-06-01), Chapman et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4689986 (1987-09-01), Carson et al.
patent: 4718433 (1988-01-01), Feinstein
patent: 4728575 (1988-03-01), Gamble et al.
patent: 4728578 (1988-03-01), Higgins et al.
patent: 4731239 (1988-03-01), Gordon
patent: 4737323 (1988-04-01), Martin et al.
patent: 4774958 (1988-10-01), Feinstein
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4781871 (1988-11-01), West, III et al.
patent: 4790891 (1988-12-01), Halliday et al.
patent: 4830858 (1989-05-01), Payne et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4863717 (1989-09-01), Keana
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4877561 (1989-10-01), Iga et al.
patent: 4893624 (1990-01-01), Lele
patent: 4895719 (1990-01-01), Radhakrishnan
patent: 4898734 (1990-02-01), Mathowitz et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4921706 (1990-05-01), Roberts et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4938947 (1990-07-01), Nicolau et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4981692 (1992-01-01), Popescu et al.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 4996041 (1991-02-01), Arai et al.
patent: 5000960 (1991-03-01), Wallach
patent: 5008050 (1991-04-01), Cullis et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5045304 (1991-09-01), Schneider et al.
patent: 5049388 (1991-09-01), Knight et al.
patent: 5088499 (1992-02-01), Unger
patent: 5114703 (1992-05-01), Wolf et al.
patent: 5123414 (1992-06-01), Unger
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5149319 (1992-09-01), Unger
patent: 5171755 (1992-12-01), Kaufman
patent: 5186922 (1993-02-01), Shell et al.
patent: 5190982 (1993-03-01), Erbel et al.
patent: 5194266 (1993-03-01), Abra et al.
patent: 5195520 (1993-03-01), Schlief et al.
patent: 5196183 (1993-03-01), Yudelson et al.
patent: 5198225 (1993-03-01), Meybeck et al.
patent: 5205287 (1993-04-01), Erbel et al.
patent: 5209720 (1993-05-01), Unger
patent: 5213804 (1993-05-01), Martin et al.
patent: 5215680 (1993-06-01), D'Arrigo
patent: 5219538 (1993-06-01), Henderson et al.
patent: 5228446 (1993-07-01), Unger et al.
patent: 5230882 (1993-07-01), Unger
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5305757 (1994-04-01), Unger et al.
patent: 5310540 (1994-05-01), Giddey et al.
patent: 5316771 (1994-05-01), Barenholz et al.
patent: 5334381 (1994-08-01), Unger
patent: 5350571 (1994-09-01), Kaufman et al.
patent: 5352435 (1994-10-01), Unger
patent: 5380519 (1995-01-01), Schneider et al.
patent: 5393524 (1995-02-01), Quay
patent: 5409688 (1995-04-01), Quay
patent: 5410516 (1995-04-01), Uhlendorf et al.
patent: 5413774 (1995-05-01), Schneider et al.
patent: 5425366 (1995-06-01), Reinhardt et al.
patent: 5433204 (1995-07-01), Olson
patent: 5445813 (1995-08-01), Schneider et al.
patent: 5470582 (1995-11-01), Supersaxo et al.
patent: B14229360 (1991-11-01), Schneider et al.
Miller, Ultrasonics (Sep. 1981) "Ultrasonic detection of resonant cavitation bubbles in a flow tube by their second-harmonic bubbles in a flow tube by their second-harmonic emissions,"pp. 217-224.
Fitzpatrick, et al., "Metal Ion Catalyzed Decarboxylation: Kinetics and Mechanism of the Oxidative Decarboxylation of Copper (II) Complexes of Aminomalonic Acid in Aqueous Solution", Inorganic Chemistry, vol. 13, No. 3, pp. 568-574 (1974).
Thanassi, "Aminomalonic Acid: Spontaneous Decarboxylation and Reaction with 5-Deoxypridoxal", Biochemistry, vol. 9, No. 3, pp. 525.532 (1970).
Stelmashok et al., Koordinatsionnaya Khimiya, vol. 3, No. 4, pp. 524-527 (1977) (Russina and English language versions).
Mayhew et al., "High-Pressure Continuous-Flow System for Drug Entrapment in Liposomes", Methods in Enzymology vol. 149, pp. 64-77 (1987).
Mayhew et al., "Characterization of Liposomes Prepared Using a Microemulsifier", Biochimica et Biophysica Acta, vol. 775, pp. 169-174 (1984).
Hope et al., "Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure: Characterization of Size Distribution, Trapped Volume, and Ability to Maintain a Membrane Potential", Biochimica et Biophysica Acta, 812: 55-65 (1985).
Mayer et al., "Vesicles of Variable Size Produced by a Rapid Extrusion Procedure", Biochimica et Biophysica Acta, vol. 858, pp. 161-168 (1986).
Cheng, et al., "The Production and Evaluation of Contrast-Carrying Liposomes Made with an Automatic High Pressure System", Investigative Radiology, vol. 22, pp. 47-55 (1987).
Jain, et al., Introduction to Biological Membranes, Ch. 9, pp. 192-231 (J. Wiley and Sons, N.Y. 1980).
Sigel, H. ed., Metal Ions in Biological Systems: Antibiotics and Their Complexes, vol. 19 (Marcel Dekker, N.Y, 1985).
Nayar et al., "Generation of Large Unilamellar Vesicles From Long-chain Saturated Phosphatidylcholines by Extrusion Technique", Biochimica et Biophysica Acta, vol. 86, pp. 200-206.
Hope et al., "Generation of Multiamellar and Unilamellar Phospholipid Vesicles", Chemistry and Physics of Lipids, vol. 40, pp. 89-107 (1986).
Mattrey et al., "Perfluorochemicals as US Contrast Agents for Tumor-Imaging and Hepatosplenography: Preliminary Clinical Results", Radiology, vol. 145, pp. 759-762 (1982).
Keller et al., "Successful Left Ventricular Opacification Following Peripheral Venous Injection of Sonicated Contrast Agent: An Experimental Evaluation", LV Contrast Echocardiography, vol. 114, No. 3, pp. 570-575 (1987).
Feinstein et al., "Two-Dimensional Contrast Echocardiography, I: In Vitro Development and Quantitative Analysis of Echo Contrast Agents", JACC, vol. 3, No. 1, pp. 14-20 (1984).
Ten Cate et al., "Two-Dimensional Contrast Echocardiography, II: Transpulmonary Studies", JACC, vol. 3, No. 1, pp. 21-27 (1984).
Unger et al., "Hepatic Metastases: Liposomal Gd-DTPA-enhanced MR Imaging", Radiology, vol. 171, pp. 81-85 (1989).
Deamer et al., "Permeability of Lipid Bilayers to Water and Ionic Solutes", Chemistry and Physics of Lipids, vol. 40, pp. 167-188 (1986).
Gutknecht et al., "Diffusion of Carbon Dioxide Through Lipid Bilayer Membranes: Effect of Carbonic Anhydrates, Bicarbonate, and Unstirred Layers", Chemical Abstracts, 87:34772q (1977).
Scarpa et al., "Cation Permeability of Liposomes as a Function of the Chemical Composition of the Lipid Bilayers", Biochimica et Biophys

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