Liposomes

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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4284022, A61K 9127, A61K 9133

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active

061327638

ABSTRACT:
Liposomes with covalently bound PEG moieties on the external surface which demonstrate improved serum half-life following intravenous administration are provided.

REFERENCES:
patent: 2310679 (1943-02-01), De Groote et al.
patent: 4016100 (1977-04-01), Suzuki et al.
patent: 4320121 (1982-03-01), Sears
patent: 4415665 (1983-11-01), Mosbach et al.
patent: 4426330 (1984-01-01), Sears
patent: 4507217 (1985-03-01), Sears
patent: 4534899 (1985-08-01), Sears
patent: 4684625 (1987-08-01), Eppstein et al.
patent: 4740304 (1988-04-01), Tjerneld et al.
patent: 4904479 (1990-02-01), Illum
patent: 4981692 (1991-01-01), Popescu
patent: 5013556 (1991-05-01), Woodle
patent: 5192548 (1993-03-01), Barenolz et al.
patent: 5213804 (1993-05-01), Martin et al.
patent: 5225212 (1993-07-01), Martin et al.
patent: 5349052 (1994-09-01), Delgado et al.
patent: 5356633 (1994-10-01), Woodle et al.
patent: 5527528 (1996-06-01), Allen et al.
patent: 5620689 (1997-04-01), Allen et al.
Roding in Seifen-Ole-Felle-Wachse. 116 p. 509, 1990.
Deamer in Liposomes. Chap. I. pp. 27-51, 1983.
STN File Server (Karlsruhe) Chemical Abstracts, vol. 109, No. 3, (1988) (Colombus, Ohio, U.S.). Hoffman et al., "Transfer of functional insulin receptors to receptor-deficient target cells" (abstract No. 17441m and Endocrinology 122 :2865-2872).
Unger et al., "Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging" Radiology (1989) 171:81-85.
Szoka, Jr., "Comparative properties and methods of preparation of lipid vesicles (liposomes)" Ann. Rev. Biophys. Bioeng. (1980) 9:467-508.
Allen et al., "Gangliosides reduce leakage of aqueous-space markers from liposomes in the presence of human plasma" Biochem. Biophys. Acta (1985) 818:205-210.
Ghosh et al., "Grafting of different glycosides on the surface of liposomes and its effect on the tissue distribution of .sup.125 I-labelled y-globulin encapsulated in liposomes" Biochem. Biophys. Acta (1980) 632:562-572.
Senior, "Fate and behavior of liposomes in vivo: A review of controlling factors" CRC Critical Reviews in Therapeutic Drug Carriers (1987) 3: 123-193.
Tilcock et al., "Liposomal Gd-DTPA: Preparation and characterization of relaxivity" Radiology (1989) 171:77-80.
Tilcock et al., "Aqueous two-phase polymer partitioning of lipid vesicles of defined size and composition" Biochem. Biophys. Acta (1989) 979:208-214.
Senior et al., "Tissue distribution if liposomes exhibiting long half-lives in the circulation after intravenous injection" Biochim. Biophys. Acta (1985) 839:1-8.
Hope et al., "Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential" Biochim. Biophys. Acta (1985) 812:55-65.
Hope et al., "Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles" J. Biol. Chem. (1987) 262:4360-4366.
Senior et al., "Methodology in assessing liposomal stability in the presence of blood, clearance from the circulation of injected animals, and uptake by tissues" Liposome Technology (1984) CRC Press, Chapter 17, 3:263-282.
Budavari et al. The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, Eleventh Edition pg. 1139, Published by Merck & Co., Inc. Rahway, N.J. (1989).
Chaabouni et al., "Affinity Partition of Proteins in Aqueous Two-Phase Systems Containing Polyoxyethylene Glycol-Bound Ligand and Charged Dextrans," Journal of Chromatography, vol. 117:135-143 (1979).
Chemical Abstracts, vol. 109(9), abstract 69845r, Aug. 29, 1988, L. Karr et al., "Cell Separation by immunoaffinity partitioning with polyethylene glycol-modified protein A in aqueous polymer two-phase systems" J. Chromatogr., vol. 442:219-27 (1988).
Chemical Abstracts, vol. 90(21), abstracts 164184, May 21, 1979, A Chaabouni et al., "Affinity partition of proteins in aqueous two-phase systems containing polyoxyethylene glycol-bound ligand and charged dextrans," J. Chromatogr., vol. 171:135-143 (1979).
Cullis et al., "Lipid Polymorphism and the Roles of Lipids in Membranes," Chemistry and Physics of Lipids, vol. 40:127-144 (1986).
Delgado et al., "Coupling of PEG to Proteins by Activation with Tresyl Chloride. Applications in Immunoaffinity Cell Partitioning," in Separations Using Aqueous Phase Systems, editors Fisher, D., and Sutherland, I.A., Plenum Press, New York, pp. 203-210 & 211-213 (1989).
Demiroglou, A. et al., "A Novel Reaction Sequence for the Coupling of Nucleophiles to Agarose with 2,2,2-Trifluoroethanesulfonyl Chloride," Angew. Chem. Int. Ed. Engl., vol. 33(1):120-123 (1994).
Gais, H-J and Ruppert, S., "Modification and Immobilization of Proteins with Polyethylene Glycol Tresylates and Polysaccharide Tresylates: Evidence Suggesting a Revision of the Coupling Mechanism and the Structure of the Polymer-Polymer Linkage," Tetrahedron Letters, vol. 36(22):3837-3838 (1995).
Harris et al., "New Activated PEG Derivatives for Affinity Partitioning," in Separations Using Aqueous Phase Systems, editors Fisher, D., and Sutherland, I.A., Plenum Press, New York, pp. 203-210 (1989).
Karr et al., "Cell Separation by Immunoaffinity Partitioning with Polyethylene Glycol-Modified Protein A in Aqueoud Polymer Two-Phase System," Journal of Chromatography, vol. 442:219-227 (1988).
King, J.F. and Gill, M.S., "Reactions of Neopentyl 2,2,2-Trifluoroethanesulfonate (Tresylate) with Nucleophiles: A Model Study for the Coupling of Nucleophiles with Tresyl Agarose," Angew. Chem. Int. Ed. Engl., vol. 34(15):1612-1613 (1995).
March, J. Advanced Organic Chemistry (2nd Edition), McGraw-Hill Kogakusha Ltd., pp. 326-327.
New R., "Introduction," Liposomes: a practical approach, Edited by R.R.C. New, Oxford University Press (1990).
Nilsson, K. and Mosbach, K., "Immobilization of Ligands with Organic Sulfonyl Chlorides," Methods in Enzymology, vol. 104:56-69 (1984).
Nilsson, K. and Mosbach, K., "Immobilization of Enzymes and Affinity Ligands to Various Hydroxyl Group Carrying Supports Using Highly Reactive Sulfonyl Chlorides," Biochemical and Biophysical Research Communications, vol. 102(1):449-457 (1981).
Nilsson, K. and Mosbach, K., "Tresyl Chloride-Activated Supports for Enzyme Immobilizations," Methods in Enzymology, vol. 135:65-78 (1987).
Watts et al., "Phospholipid phase transitions as revealed by NMR," Chemistry and Physics of Lipids, vol. 57:195-211 (1991).

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