Liposome preparation

Details Liposome preparation Liposome preparation

1991-04-05

1992-10-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

552544, 562563, 562576, A61K 9127

Patent

active

051529998

ABSTRACT:
The present invention relates to liposome preparations. In particular, the present invention relates to Adriamycin-entrapped liposome preparations comprising cholesterol derivatives having a negative charge as a liposome membrane constituent. Adriamycin-entrapped liposome preparations have many uses in the medical field such as maintaining high Adriamycin blood levels over a long period of time and reducing systemic toxicity, for example.

REFERENCES:
patent: 4721612 (1988-01-01), Janoff et al.
patent: 4804539 (1989-02-01), Guo et al.
patent: 4927571 (1990-05-01), Huang et al.
Ahmad et al, "Lithium Aluminium Hydride-Aluminium Chloride Reduction of Steroidal Cyclic Acetals," Aust. J. Chem., 24: 143-151 (1971).

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