Liposome preferentially traveling to cardiac and skeletal muscle

Details Liposome preferentially traveling to cardiac and skeletal muscle Liposome preferentially traveling to cardiac and skeletal muscle

1992-07-08

1999-03-02

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514 78, 514821, 554 79, 554 80, A61K 9127, A61K 31685

Patent

active

058767479

ABSTRACT:
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active compound can be a protease inhibitor, a cardioactive drug for combating arrythmia, etc. The linkage is chemical through one or more alcohol, carboxyl or amine groups using reagents such as glutaraldehyde, dicarboxylic acid anhydrides and acid halides and carbodiimides. Carnitine derivatives are also incorporated into liposomes which are then used as carriers of active pharmaceutical agents.

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