Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1979-03-26
1980-04-22
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Lymphokine
424 88, 424 92, A61K 3912, A61K 3902, A61K 3918
Patent
active
041995651
ABSTRACT:
Subunit viral or bacterial antigens are incorporated into liposomes containing a positively charged amino-containing surfactant. The resulting complex is antigenically more active than the free antigen.
REFERENCES:
patent: 4053585 (1977-10-01), Allison et al.
patent: 4117113 (1978-09-01), Allison et al.
patent: 4148876 (1979-04-01), Almeida et al.
Chem. Abstracts 89 #157972d, #1994b 88 #1961t #20444t #35717h (1978); 87 #50741j #11609c #130406u (1977).
Allison et al., Nature 252, Nov. 15, 1974: 252 "Liposomes as Immunological Adjuvants".
Manesis et al., Biochem Soc. Trans. 6(5) 925-928 (1978), Incorporation of Heptatis-B Surface Antigen (HBsAG) Into Liposomes.
Van Rooijen et al., Immunol. Commun. 1977 6(5) 489-498 7(6) 635-644 (1978), Liposomes in Immunology: The Immune Response Against Antigen-Containing Liposomes; Further Evidence for the Adjuvant Activity of Liposomes.
Morein et al., Nature 276 (5689), 715-718, Dec. 14, 1978, Effective Subunit Vaccines Against an Enveloped Virus.
Almeida et al., Lancet, Nov. 8, 1975, 899-901, Formation of Virosomes from Influenza Subunits and Liposomes.
Levitt Julian S.
Merck & Co. , Inc.
Perrella Donald J.
Rose Shep K.
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