Liposome methods and compositions

Details Liposome methods and compositions Liposome methods and compositions

1985-04-22

1987-05-05

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Lymphokine

424450, 264 46, 436829, 4284022, A61K 942, A61K 3912

Patent

active

046631615

ABSTRACT:
The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an efficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles with a large, internal aqueous space. The method has been exemplified with the use of glycoproteins of influenza (A/PR8/34) and Sendai (parainfluenza type I) viruses.

REFERENCES:
patent: 4148876 (1979-04-01), Almeida et al.
patent: 4196191 (1980-04-01), Almeida et al.
patent: 4201767 (1980-05-01), Fullerton et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4261975 (1981-04-01), Fullerton et al.
patent: 4356169 (1982-10-01), Simons et al.
Scheid et al.: "Identification of Biological Activities of Paramyxovirus Glycoproteins . . . ", Virology, 57, 475-490 (1974).
Papahadjopoulos et al.: "Cochleate Lipid Cylinders: Formation by Fusion of Unilamellar Lipid Vesicles", Biochimica et Biophysica Acta, 394 (1975), 483-491.

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