Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1987-10-27
1991-01-01
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424426, 424450, 4284022, A61K 9127
Patent
active
049816900
ABSTRACT:
The present invention involves a liposomal agent for treating disseminated fungal infection in an animal. This liposomal agent comprises the polyene antifungal compound mepartricin. The mepatricin is encapsulated within a liposome. The liposome in which the mepartricin is incorporated is preferably a stable multilamellar vesicle. The liposome broadly comprises one or more lipids one or more of phosphomonoglyceride, phosphatidic acid and sphingolipid. The lipids are preferably one or more of phosphatidylcholine, phosphatidylserine, phosphatidylglycerol, sphingomyelin or phosphatidic acid. The lipids are most preferably one or more of dimyristoylphosphatidylchlorine, dimyristoylphosphatidylglycerol, phosphatidylcholine and phosphatidylglycerol. The liposome of the present invention may comprise a sterol most preferably cholesterol. An important aspect of the present invention involves a method for treating disseminated fungal infection in an animal. This method comprises administering to an animal subject to disseminated fungal infection a fungicidally effective amount of mepartricin encapsulated within a liposome. The liposome is composed as described above. The administering is preferably parenteral in most instances but may be oral or topical if specific colonies of fungus are thereby more directly reached. This treatment method is most useful when the animal is a human suffering from disseminated fungal infection. The method of treatment involves a fungicidally effective amount of liposome-incorporated mepartricin of between about 1 mg mepartricin/kg body weight and about 6 mg mepartricin/kg body weight.
REFERENCES:
patent: 3773925 (1973-11-01), Bruzzese et al.
patent: 3780173 (1973-12-01), Bruzzese et al.
patent: 4016100 (1977-04-01), Suzuki et al.
patent: 4145410 (1979-03-01), Sears
patent: 4186183 (1980-01-01), Steck et al.
patent: 4235871 (1980-11-01), Papahadjopoulos
patent: 4241046 (1980-12-01), Papahadjopoulos
patent: 4330534 (1982-05-01), Sakurai et al.
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4663167 (1987-05-01), Lopez-Berestein et al.
patent: 4707470 (1987-11-01), Kirsh et al.
patent: 4725442 (1988-02-01), Haynes
patent: 4744989 (1988-05-01), Payne et al.
patent: 4766046 (1988-08-01), Abra et al.
patent: 4812312 (1989-03-01), Lopez-Berestein
patent: 4863739 (1989-09-01), Perez-Soler
Mehta et al., "Effect of Liposome Encapsulation on Toxicity . . . ", in Liposomes in the Therapy of Infectious Diseases and Cancer, (1989), Alan R. Liss, Inc., pp. 263-273.
Lopez-Berestein et al., `Treatment and Prophylaxis . . . with Liposome-Encapsulated Amphotericin B`, J. Infect. Dis, vol. 147, No. 5 (1983), pp. 939-945.
Chem. Abst., vol. 84, No. 25, abs. #174,021e, Bruzzese et al., Farmaco Ed. Sci, 31(4) 291-6, (1976).
Chem. Abst., vol. 103, No. 19, abs #157, 200h, Petrov et al., J. Antimicrob. Chemother, 16(2), 169-77, (1985).
Merck Index, 10th Ed., Citation #6909, p. 1011, 1983.
Merck Index, 10th Ed., Citation #611, p. 85, 1983.
Szoka, et al., Ann. Rev. Biophys. BioEng. (1980) 9:467-508.
Mehta et al., "Effect of Liposome Encapsulation on Toxicity and Antifungal Activity of Polyene Antibiotics" (1988).
Graybill, et al., J. Infect. Dis., 145:748-752 (1982).
Tremblay, et al., Abst., 1983 ICAAC No. 755, p. 222 (1983).
Graybill, et al., Abst., 1928 ICAAC No. 492, p. 152 (1982).
Mehta, et al., Biochim. Biophy. Acta, 770:230-234 (1984).
Hopfer, et al., Antimicrob. Agents and Chemo., 25:387-389 (1984).
Lopez-Berestein, et al., Cancer Drug Delivery, 1:37-42 (1983).
Partricin and Mepartricin Chemical Abstracts, pp. 1011-1012 (undated).
Search Report of Dialog Search of the Scientific Literature.
Hopfer Roy L.
Juliano Rudolph L.
Lopez-Berestein Gabriel
Mehta Reeta
Board of Regents , The University of Texas System
Covert John M.
Lovering Richard D.
LandOfFree
Liposome-incorporated mepartricin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Liposome-incorporated mepartricin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposome-incorporated mepartricin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1995112