Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1992-10-28
1995-04-25
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
424423, 424450, 4242831, 424812, A61K 3900, A61K 3722, A61K 952, B01J 1302
Patent
active
054096987
ABSTRACT:
The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in combination with adoptively transferred cells stimulated with anti-CD3 monoclonal antibody plus IL-2.
REFERENCES:
patent: 4199565 (1980-04-01), Fullerton
patent: 4235877 (1980-11-01), Fullerton
patent: 4311712 (1982-01-01), Evans et al.
patent: 4370349 (1983-01-01), Evans et al.
patent: 4464355 (1984-08-01), Fabricius et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4565696 (1986-01-01), Heath et al.
patent: 4599227 (1986-07-01), Dees et al.
patent: 4604377 (1986-08-01), Fernandes et al.
patent: 4636463 (1987-01-01), Altman et al.
patent: 4663161 (1987-05-01), Mannino et al.
patent: 4683199 (1987-07-01), Palladino
patent: 4684625 (1987-08-01), Eppstein et al.
patent: 4689222 (1987-08-01), McMichael
patent: 4690915 (1987-09-01), Rosenberg
patent: 4721612 (1988-01-01), Janoff et al.
patent: 4752425 (1988-06-01), Martin et al.
patent: 4774085 (1988-09-01), Fidler
patent: 4781871 (1988-11-01), West, III et al.
patent: 4808151 (1989-02-01), Dunn, Jr. et al.
patent: 4844904 (1989-07-01), Hamaguchi et al.
patent: 4971802 (1990-11-01), Tarcsay et al.
patent: 5030453 (1991-07-01), Lenk et al.
patent: 5100664 (1992-03-01), Doyle et al.
T. D. Geppert et al., J. Clin. Invest., 81, 1497 (1988).
E. A. Grimm et al., J. Exp. Med., 155, 1823 (1982).
M. T. Lotze et al., Cancer Res., 41, 4420 (1981).
M. T. Lotze et al., J. Surg. Res., 42, 580 (1987).
E. Lotzova et al., Nat. Immun. Cell Growth Regul., 6, 219 (1987).
G. B. Mills et al., J. Cell. Physiol., 141, 310 (1989).
R. P. Moser et al., Int'l. Symp. on Pediatric Neuro-Oncology, Jun. 1-3, 1989, Seattle, Wash., Meeting Abstract No. A14.
S. Rosenberg, J.N.C.I., 75, 595 (1985).
P. M. Sondel et al., J. Immunol., 137, 502 (1986).
J. Stankova et al., FASEB, 2, (1988) Abstract No. 2114, 72nd Annual Meeting of FASEB, May 1988 (Meeting Abstract).
J. Stankova et al., Cell. Immunol., 121, 13 (1988).
M. C. Turco et al., Blood, 74, 1651 (1989).
W. H. West et al., J. Immunol., 118, 355 (1977).
G. Strauss et al., Biochem. Biophys. Acta, 1986, 858, 169.
J. L. Strausser et al., J. Immunol., 1978, 121, 1491.
A. B. Stravitsky, J. Immunol., 1954, 72, 360.
L. Tan et al., Biochemical Society Transactions, 1989, 17, 693.
V. von Fliedner et al., Progress in Chemical and Biological Research: Cellular Immunotherapy of Cancer, 1987, 244, 223.
B. M. Vose, Int. J. Cancer, 1982, 30, 135.
A. Weinberg et al., J. Immunol., 1988, 140, 294.
A. Weiss et al., J. Clin. Immunol., 1984, 4, 165.
T. L. Whiteside et al., Int. J. Cancer, 1986, 37, 803.
J. M. Williams et al., J. Immunol., 1985, 135, 2249.
J. M. Zarling et al., Nature, 1978, 274, 269.
O. Zumbuehl et al., Biochem. Biophys. Acta, 1981, 640, 252.
S. C. Yang et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., 29 (1988), Abstract No. A1603 (Meeting Abstract).
Y. P. Yen et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., 28 (1987), Abstract No. 403 (Meeting Abstract); and Y. P. Yen et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., 29 (1988), Abstract No. A1616 (Meeting Abstract).
J. M. Zarling et al., Cancer Immunol. Immunother., 15, 237 (1983).
S. A. Rosenberg et al., N. Engl. J. Med., 1985, 313, 1485.
S. A. Rosenberg et al., N. Engl. J. Med., 1987, 316, 889.
S. A. Rosenberg et al., Science, 1986, 233, 1318.
D. G. Russell et al., J. Immunol., 1988, 140, 1274.
B. E. Ryman et al., Essays in Biochemistry, 1980, 16, 49.
R. R. Salup et al., Cancer Immunol. Immunother., 1986, 22, 31.
R. Schwab et al., J. Immunol., 1985, 135, 1714.
S. Shu et al., J. Immunol., 1986, 136, 3891.
S. Shu et al., J. Immunol., 1985, 135, 2895.
K. A. Smith, Science, 1988, 240, 1169.
S. Sone et al., Cell Immunol., 1981, 57, 42.
S. Sone et al., J. Immunol., 1980, 125, 2454.
G. Strauss et al., Proc. Natl. Acad. Sci. USA, 1986, 83, 2422.
A. C. Ocha et al., Cancer Res., 1989, 49, 963.
A. C. Ochoa et al., J. Immonol., 1987, 138, 2728.
J. R. Ortaldo et al., Int. J. Cancer, 1983, 31, 285.
G. Poste et al., Cancer Research, 1979, 39, 881.
M. J. Poznansky and R. L. Juliano, Pharmacol. Rev., 1984, 36, 277.
H. Rabinowich et al., Cancer Res., 1987, 47, 173.
A. Rahman et al., Cancer Res., 1982, 42, 1817.
S. A. Rosenberg, in Important Advances in Oncology, V. T. DeVita et al., eds., J. P. Lippincott Co., Philadelphia, Pa. (1988) at pp. 217 to 257.
S. A. Rosenberg et al., J. Immunol, 1978, 121, 1951.
S. A. Rosenberg et al., Adv. Cancer Res., 1977, 25, 323.
S. A. Rosenberg et al., Ann. Int. Med., 1988, 108, 853.
S. A. Rosenberg et al., Ann. of Surg., 1988, 208, 121.
E. M. Janis et al., Science, 1989, 244, 713.
M. Kende et al., Antimicrobial Agents and Chemotherapy, 1985, 27, 903.
H. Konno et al., Chemical Abstracts, 1989, 110, No. 19, 624, Abstract No. 171523s.
S. S. Kulkarni et al., Annals of the New York Academy of Sciences, 1987, 507, 344.
O. Leo et al., Proc. Natl. Acad. Sci. USA, 1987, 84, 1374.
G. Lopez-Berestein, Ann. Int. Med., 1986, 105, 130.
M. Malkovsky et al., Nature, 1987, 325, 262.
S. C. Meuer et al., Proc. Natl. Acad. Sci. USA, 1984, 81, 1509.
S. Miescher et al., J. Immunol., 1986, 136, 1899.
J. J. Mule et al., Science, 1984, 225, 1487.
L. M. Muul et al., J. Immunol., 1987, 138, 989.
L. M. Muul et al., J. Immunol. Meth., 1986, 88, 26.
J. H. Nunberg et al., J. Cell. Biochem., 1988, Supp. 128, 12.
J. H. Frenster et al., in Proc. 5th Leukocyte Culture Conference, J. E. Harris, ed. (1970), p. 359.
C. J. Froelich et al., J. Immunol. Meth., 1986, 86, 205.
J. Fujita, Eur. J. Cancer Clin. Oncol., 1986, 22, 445.
Anderson Peter M.
Leonard Arnold S.
Loeffler Cynthia
Ochoa Augusto C.
Schain Howard E.
The Regents of the University of Minnesota
Touzeau P. Lynn
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