Liposome for incorporating large amounts of hydrophobic...

Details Liposome for incorporating large amounts of hydrophobic... Liposome for incorporating large amounts of hydrophobic...

2003-07-23

2009-02-03

Pak, John (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C514S077000, C514S114000, C514S121000, C514S129000, C514S283000, C514S410000, C514S422000, C514S426000, C514S428000, C514S449000, C514S511000, C514S513000, C514S529000, C514S532000, C514S533000, C514S534000, C514S617000, C514S649000, C514S656000, C514S725000

Reexamination Certificate

active

07485320

ABSTRACT:
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as saturated and unsaturated phosphatidyl cholines, hydrophobic substances, cholesterol, cholesterol derivatives, antioxidant and hydrophilic polymer-modified lipids such as MPEG-DSPE.

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Kan, Pei, et al., Formulation of Liposomal Taxol and Process Development, Proceedings of the International Symposium on Controlled Release of Bioactive Materials, 27th, pp. 303-304, Industrial Technology Research Institute, 2000, Controlled Release Society, Inc., Hsinchu, Taiwan.

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