Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1998-06-23
2000-09-19
Guzo, David
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514 44, 435458, 536 231, 536 245, A61K 9127, A61K 4800, C12N 1585
Patent
active
061207985
ABSTRACT:
A liposome composition for administration of a polynucleotide and a method of preparing the composition are described. The liposomes in the suspension are composed predominantly of liposomes having a bilayer membrane formed of cationic vesicle-forming lipids and neutral vesicle forming lipids. The polynucleotide is entrapped in the central core of the liposomes and is localized predominantly on the inner surface of the core.
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Allen Theresa M.
Stuart Darrin D.
ALZA Corporation
Guzo David
Mohr Judy M.
Shuman Jon
Simboli Paul B.
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