Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-03-07
2006-03-07
Epps-Ford, Janet L. (Department: 1633)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C424S450000, C435S455000, C514S04400A
Reexamination Certificate
active
07008791
ABSTRACT:
An oral vaccine contain liposomes and complexed or, preferably entrapped, DNA operatively encoding an antigen in which the liposomes are formed from components including cationic compounds and zwitterionic phospholipids. The hydrophobic groups within the liposome forming components must include at least one group which is saturated. This is believed to raise the transition temperature, rendering the liposomes more stable when delivered orally. The compositions have been found to give detectable increased in IgA levels, secreted immunoglobulins of importance in efficacious oral vaccine delivery.
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Perrie et al., “Genetic Immunization Using Liposome-Incorporated DNA”, J. Pharm. Pharmacol. 50 (Supplement) 103 (1998).
Gregoriadis et al., “Liposome-Mediated DNA Vaccination”, FEBS Letters 402, pp. 107-110 (1997).
Han et al., “Application of Liposomes for Development of Oral Vaccines: Study of In Vitro Stability of Liposomes and Antibody Response to Antigen Associated with Liposomes After Oral Immunization” Journal of Veterinary Medical Science vol. 50 No. 12 (Dec. 1997).
Gregoriadis Gregory
Perrie Yvonne
Dickstein Shapiro Morin & Oshinsky LLP.
Epps-Ford Janet L.
Jacobs D
Lipoxen Technologies Limited
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