Liposome-encapsulated vinca alkaloids and their use in combattin

Details Liposome-encapsulated vinca alkaloids and their use in combattin Liposome-encapsulated vinca alkaloids and their use in combattin

1988-05-23

1990-08-28

Thexton, Matthew A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 514883, 514908, A16K 3722, B01J 1302

Patent

active

049524089

ABSTRACT:
A composition made up of a liposome-encapsulated vinca alkaloid is disclosed. This composition possesses an increased antitumor activity and a substantially lower toxicity as compared to free drug.

REFERENCES:
patent: 4331654 (1982-05-01), Morris
patent: 4362664 (1982-12-01), Gerzon et al.
patent: 4479957 (1984-10-01), Cullinan et al.
patent: 4565696 (1986-01-01), Heath et al.
patent: 4663167 (1987-05-01), Lopez-Berenstein et al.
patent: 4711782 (1987-12-01), Okada et al.
The Merck Index, 10th edition, Merck and Co., Inc., Rahway, N.J., U.S.A., 1983, pp. 1427-1429.

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