Liposome encapsulated taxol and a method of using the same

Details Liposome encapsulated taxol and a method of using the same Liposome encapsulated taxol and a method of using the same

1993-10-14

1995-06-13

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, A61K 9127

Patent

active

054240735

ABSTRACT:
Liposomal-encapsulated taxol or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer, and which may be used advantageously in combination with hyperthermia. The liposomes confer enhanced stability and solubility to taxol or derivatives thereof.

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patent: 4898735 (1990-02-01), Barenholz
patent: 4952408 (1990-08-01), Rahman
patent: 4960790 (1990-10-01), Stella
patent: 5059591 (1991-10-01), Janoff
patent: 5094854 (1992-03-01), Ogawa
Rahman et al Cancer Res. 42, 1817, 1982.
Ostro. Am J. Hosp. Pharm. 46, 1579, 1989.
Cancer Resarch, vol. 42, pp. 1817-1821 (1982) (Rahman) "Doxorubicin -induced Chronic Cardiotoxicity and Its Protection by Liposomal Administration".
Rosa, Transport in Biomembranes: Model Systems & Reconstitution. ed. by Antolini. 1982, p. 243.

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