Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1987-07-13
1989-10-10
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514970, 514974, 514 54, A61K 952, A61K 4900, B01J 1302
Patent
active
048730882
ABSTRACT:
A method for enhancing the therapeutic effectiveness of adriamycin, in the treatment of cancer, is disclosed. Liposomes containing coentrapped adriamycin and a secondary compound effective to reduce the toxicity of adriamycin or enhance the induction by adriamycin of the tumoricidal activity of host lymphoid cells, such as lipopolysaccharide, are administered parenterally in a therapeutically effective dose. In another aspect, macrophages stimulated in vivo with liposomes containing entrapped liposomes are exposed to an immunostimulator, for enhanced tumoricidal activity. Also disclosed are liposome compositions containing coentrapped adriamycin and an immunostimulator.
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Ehrke M. Jane
Mace Kenneth
Mayhew Eric
Olson Fred C.
Szoka Francis
Dehlinger Peter J.
Dolezalova Hana
Griffin Ronald W.
Liposome Technology, Inc.
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