Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1988-10-12
1990-02-06
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 41, 264 43, 264 46, 428402, 536 5, A01N 2500, A61K 3165
Patent
active
048987352
ABSTRACT:
A drug/liposome composition comprising an aqueous suspension of liposomes and, entrapped in the lipid bilayer region of the liposomes, an anthraquinone drug containing quinone and hydroquinone functionalities on adjacent anthracene rings. An iron-specific trihydroxamic chelating agent contained in the bulk aqueous phase of the suspension and a lipophilic free-radical scavenger contained in the bilayer region of the liposome cooperate to reduce chemical modification of both drug and lipid components of the composition. A preferred composition containing doxorubicin and alpha-tocopherol entrapped in the liposomes, and ferrioxamine in the aqueous suspension phase is effective in treating human neoplasms, with significantly reduced side effects over those produced by free-drug administration.
REFERENCES:
patent: 4460560 (1984-07-01), Tokes et al.
patent: 4610868 (1986-09-01), Fountain et al.
Chemical Abstracts 95:12709n (1981).
Barenholz Yechezkel
Gabizon Alberto
Dehlinger Peter J.
Hadassah Medical Organization
Robinson Douglas W.
Weddington Kevin E.
Yissum Research and Development Company of the Hebrew University
LandOfFree
Liposome/doxorubicin composition and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Liposome/doxorubicin composition and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposome/doxorubicin composition and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-440984