Liposome dispersion

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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264 41, 264 43, 264 46, A61K 9127

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active

055891896

ABSTRACT:
A process for the production of a non-aggregating, filterable dispersion of liposomal encapsulated hemoglobin includes the addition of a plasma protein such as human serum albumin to a liposome dispersion and the application of liposome-forming energy to the dispersion sufficient to form unilamellar vesicles having a diameter smaller than 0.2 .mu.m.

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Beissinger, Trans Am. Soc. Artif. Intern organs, vol. XXXII, p. 58 1986.
Farmer, Martha et al., Liposome-Encapsulated Hemoglobin as an Artificial Oxygen-Carrying System. Methods in Enzymology, vol. 149: 184, 184-194.
Rudolph, A. S., Encapsulated Hemoglobin: Current Issues and Future Goals. Art. Cells Blood Subs., and Immob. Biotech. (1994) 22(2):354-356.

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