Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2006-12-11
2010-11-02
Kishore, Gollamudi S (Department: 1612)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
Reexamination Certificate
active
07824708
ABSTRACT:
Disclosed herein is a composition comprising a liposome, a cardiolipin, and at least one antioxidant, wherein the composition is useful for improving, maintaining, or restoring a mitochondrial membrane and/or mitochondrial function. In one example, the liposome is primarily composed of phosphatidylcholine, the cardiolipin is tetraoleoyl-cardiolipin, and the at least one antioxidant is methylgentisate, l-carnosine, or both. The composition may be topically administered, orally administered, or parenterally administered, for example administered by injection. If topically administered, the composition may be administered for example, as a cream, lotion, gel, paste, spray, tonic, or other suitable form and may contain various additives, for example, one or more of an emollient, a humectant, a penetration enhancer, a vitamin, a fragrance, a pigment, and a moisturizer.
REFERENCES:
patent: 5503776 (1996-04-01), Murase et al.
patent: 2002/0048551 (2002-04-01), Keller et al.
patent: 2004/0057974 (2004-03-01), Sachdev
patent: 2004/0081681 (2004-04-01), Vromen
patent: 2005/0008665 (2005-01-01), Batzer et al.
patent: 2005/0181037 (2005-08-01), Ahmad et al.
patent: 2005/0197407 (2005-09-01), DiNardo et al.
patent: 2005/0266068 (2005-12-01), Ahmad et al.
patent: 2005/0277611 (2005-12-01), Ahmad et al.
patent: 2006/0034908 (2006-02-01), Bhamidipati et al.
patent: 2006/0216251 (2006-09-01), Morariu
patent: 0 201 956 (1986-11-01), None
patent: WO 01/49305 (2001-07-01), None
patent: WO 01/49305 (2001-07-01), None
patent: WO 03/099830 (2003-12-01), None
patent: WO 2005/079185 (2005-09-01), None
patent: WO 2006/004935 (2006-01-01), None
Bergman, Margalit et al., ‘The antioxidant activity of aqueous spinach extract: chemical identification of active fractions’,Phytochemistry, vol. 58, 2001, pp. 143-152.
Bergman, Margalit et al., ‘Scavenging of reactive oxygen species by a novel glucurinated flavonoid antioxidant isolated and purified from spinach’,Phytochemistry, vol. 62, 2003, pp. 753-762.
Lasic, Dan D., ‘Novel applications of liposomes’,Trends in Biotechnology, vol. 16, No. 7, 1998, pp. 307-321.
Lomnitski, Liat et al., Composition, Efficacy, and Safety of Spinach Extracts,Nutrition and Cancer, vol. 46, No. 2, 2003, pp. 222-231.
McMillin, Jeanie B. et al., ‘Cardiolipin and apoptosis’,Biochimica et Biophysica Acta, vol. 1585, 2002, pp. 97-107.
International Search Report for PCT/US2007/023280, dated Mar. 17, 2008, 5 pgs.
International Search Report for PCT/US2007/024617, dated Mar. 28, 2008, 4 pgs.
Notification Concerning Transmittal of International Preliminary Report on Patentability with Written Opinion of the International Search Authority for PCT/US2007/024617, dated Jun. 25, 2009, 9 pp.
Wei, Y.H., et al. “Mitochondrial Theory of Aging Matures-Roles of mtDNA Mutation and Oxidative Stress in Human Aging,” Zhonghua Yi Xue Za Zhi (Taipei), 64(5):259-70 (2001).
Mileykovskaya, E., et al., “Cardiolipin in Energy Transducing Membranes,” Biochem. (Moscow) 70(2):154-158 (2005).
Gorbenko, G.P., et al., “CytochromecInteraction with Cardiolipin/ Phosphatidylcholine Model Membranes: Effect of Cardiolipin Protonation,” Biophys. J. BioFAST, (Mar. 24, 2006).
Paradies, G., et al., “Reactive Oxygen Species Affect Mitochondrial Electron Transport Complex I Activity Through Oxidative Cardiolipin Damage,” Gene, 286:135-141 (2002).
Paradies, G., et al., “Reactive Oxygen Species Generated by the Mitrochondrial Respiratory Chain Affect the Complex III Activity Via Cardiolipin Peroxidation in Beef-Heart Submitochondrial Particles,” Mitochondrion, 1:151-159 (2001).
Kohen, R., et al., “Antioxidant Activity of Carnosine, Homocarnosine, and Anserine Present in Muscle and Brain,” Proc. Natl. Acad. Sci., USA 85:3175-3179 (1988).
The Lipid Library (on-line article), “Diphosphatidylglycerol (Cardiolipin) Structure, Occurrence, Biology and Analysis,” updated Feb. 3, 2006 http://www.lipidlibrary.co.uk/lipids/dpg/index.htm.
Petrosillo G., et al., “Role of Reactive Oxygen Species and Cardiolipin in the Release of Cytochromecfrom Mitochondria,” The FASEB J., 17:2202-2208 (2003).
Kowaltowski, A.J., et al., “Minireview: Mitochondrial Permeability Transition and Oxidative Stress,” FEBS Letters 495:12-15 (2001).
Miyoshi, N., et al., “Age-Dependent Cell Death and the Role of ATP in Hydrogen Peroxide-Induced Apoptosis and Necrosis,” PNAS, 103(6):1727-1731 (2006).
Bruce, A. “Skeletal Muscle Lipids. III. Changes in Fatty Acid Composition of Individual Phosphoglycerides in Man From Fetal to Middle Age,” J. Lipid Res., 15:109-113 (1974).
Shigenaga, M.K., et al., “Oxidative Damage and Mitochondrial Decay in Aging,” Proc. Natl. Acad. Sci. USA, 91:10771-10778 (1994).
Greco, M., et al., “Marked Aging-Related Decline in Efficiency of Oxidative Phosphorylation in Human Skin Fibroblasts,” The FASEB J. express article 10.1096/fj.02-1009jfe. Published online Jul. 18, 2003.
Hagen, T.M., et al., “Mitochondrial Decay in Aging, Reversal through Supplementation of Acetyl-L-Carnitine and N-tert-Butyl-α-phenyl-nitrone,” Ann. N.Y. Acad. Sci., 214-223.
Fast David J.
Leverett Jesse C.
Missler Stephen R.
Access Business Group International LLC
Brinks Hofer Gilson & Lione
Kishore Gollamudi S
Nichols G. Peter
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