Liposome compositions for boron neutron capture therapy and meth

Details Liposome compositions for boron neutron capture therapy and meth Liposome compositions for boron neutron capture therapy and meth

1995-08-03

1999-03-30

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424450, 564 4, 564 5, 564 8, A61K 5112, A61K 9127, C04F 502

Patent

active

058884734

ABSTRACT:
Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.

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