Liposome compositions and kits therefor

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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424 121, 424 9321, 264 41, 264 43, 264 46, A61K 9127

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active

057388687

ABSTRACT:
A method for preparing a radio labelled liposome, the method including the steps of at least once dehydrating and rehydrating a treated liposome to form a binding liposome, and adding a radio label to said binding liposome to form the radio labelled liposome.

REFERENCES:
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"Methods in Enzymology", Packer, L. Editor vol 234, Part D, p. 269.
"Use of Technetium-99m-Liposomes in Tumor Imaging", Goins, B. et al, Journ Nucl Med. 1994 pp. 1491-1498.
"Liposomes Prepared from Synthetic Amphiphiles. . ." Goto, R. et al; Chem Pharm Bull pp. 1351-1354 (1989).
"Tumor Imaging with Technetium-99m-DTPA Encapsulated. . ." Oku, N et al, Nucl Med Biol vol 20, No. 4 pp. 407-412 (1993).
"Distribution of technitium-99m-Labeled Multimellar. . ." Perez-Soler, R. et al, J. Nuc Med vol 26 No. 7 (1485) pp. 743-749.
"Properties of (.sup.99m Tc) Technetium-Labelled Liposomes. . ." Richardson, V. et al, Bioch. Soc. Trans pp. 290-291 (1977)
"Clinical Pharmacology of .sup.99m Tc-Labeled Liposomes. . ." Lopez-Berestein et al, Cancer Res. vol. 44 pp. 375-378 (1984).
"Interaction of.sup.99m Tc-Labeled Liposomes with Walker. . ." Todorou, D. et al Gen. Pharmac, vol. 14 No. 4 pp. 407-411 (1983).
"Biodistribution of 99m Tc Labelled Liposomes in Rabbits. . ." Ninlo, S et al. pp. 102-104.
"Effect of reticuloendothelial Blockade on Tissue" Goto R. et al. Chem Pharm Bull (1991) pp. 230-232.
"Wide dynamic range particle size analysis by DLS-SPOS" Nicoli, D.F. Int'l Spect. Lab. pp. 9A-9J (Sep. 95).

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