Liposome composition useful for hypertheria therapy

Details Liposome composition useful for hypertheria therapy Liposome composition useful for hypertheria therapy

1990-10-31

1992-03-10

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

264 41, 264 46, 4284022, 424450, 514963, A61K 9133, A61K 9127, B01J 1302

Patent

active

050948547

ABSTRACT:
This invention relates to the liposome compositions which are characterized in that the phase transition temperature of the membrane is in the range of 40.degree. to 45.degree. C. and the osmotic pressure of a drug-containing solution to be entrapped in liposomes is 1.2 to 2.5 times higher than that of body fluid of warm-blooded animals. The compositions are useful for treatment of solid tumors in hyperthermia therapy.

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Gruner et al., `Novel Multilayered Lipid Vesicles . . . `, Biochemistry, vol. 24, (1985) pp. 2833-2842.
Yatvin et al., Science, vol. 202, 22 Dec. 1978, pp. 1290-1292.
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Bassett et al., The Journal of Urology, vol. 135, 612-615 (1986).
Weinstein et al., Science, vol. 204, 13 Apr. 1979, pp. 188-191.
Magin et al., Chemical Abstracts 97:203147d (1982).
Ni et al., Chemical Abstracts 107:111441s (1987).
Yatvin et al., Chemical Abstracts 94:214521k (1981).
Lichtenberg et al., Biochemistry, vol. 20, 3462-3467 (1981).

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