Chemistry: analytical and immunological testing – For preexisting immune complex or auto-immune disease
Patent
1983-09-26
1987-05-26
Marantz, Sidney
Chemistry: analytical and immunological testing
For preexisting immune complex or auto-immune disease
264 46, 436507, 436829, 4284022, G01N 33564, B32B 516, B32B 902, B32B 904
Patent
active
046686380
ABSTRACT:
An immunoassay utilizing a novel liposome composition in which there is incorporated a stabilizing or destabilizing component and an antigen. The presence of cognate antibodies in test samples is detected by the alteration of the supramolecular structure of the liposomes resulting in changes in stabilization. Destabilization can be detected, and in certain cases, caused by, the addition of magnesium or calcium ions. Increased stabilization can be detected by the polymerization of bilayer components in response to ultraviolet light. Antibody-antigen interactions at the liposome surface mediate the stabilization/destabilization response.
REFERENCES:
patent: 4235792 (1980-11-01), Hsia et al.
patent: 4329331 (1982-05-01), Kallick
patent: 4448765 (1984-05-01), Ash et al.
Schieren, H. et al., Biochem. and Biophys. Res. Comm., 82 (4), pp. 1160-1167 (1978).
Weissmann, G. et al., I: J. Clin. Inves. 53, pp. 536-543 (Feb. 1974).
Weissmann, G. et al., II: Proc. Natl. Acad. Sci. U.S.A. 73(2), pp. 510-514 (Feb. 1976).
Janoff Andrew S.
Ostro Marc J.
Seibold James R.
Weiner Alan L.
Weissmann Gerald
Krawczewicz L.
Marantz Sidney
The Liposome Company Inc.
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