Liposome composition for lupus assay

Details Liposome composition for lupus assay Liposome composition for lupus assay

1983-03-24

1986-01-14

Marantz, Sidney

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

Immune complex

436506, 436829, 4284022, 424 71, 424 38, G01N 33564, B32B 516, B32B 902, B32B 904, A01N 2500, A61K 942

Patent

active

045645990

ABSTRACT:
An assay for detecting SLE antibodies utilizing a novel liposome composition in which there is entrapped a divalent cation responsive indicator. The presence of such antibodies is detected by their stabilization of the supermolecular structure of the liposomes. Such stabilization can be detected, and in certain cases, caused by, the addition of magnesium or calcium ions.

REFERENCES:
patent: 4235792 (1980-11-01), Hsia et al.
patent: 4329331 (1982-05-01), Kallick
patent: 4448765 (1984-05-01), Ash et al.
Schieren, H. et al., Biochem. and Biophys. Res. Comm., 82 (4), pp. 1160-1167, (1978).
Weissmann, G. et al., J. Clin. Inves., 53, pp. 536-543, (Feb. 1974).
Weissmann, G. et al., Proc. Natl. Acad. Sci., U.S.A., 73 (2), pp. 510-514, (Feb. 1976).

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