Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1998-04-02
1999-10-26
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 41, A61K 9127
Patent
active
059723793
ABSTRACT:
A liposome composition for treating a bacterial infection is described. The composition includes liposomes having a surface coating of hydrophilic polymer chains and an entrapped drug-conjugate composed of ciprofloxacin conjugated to an amino acid.
REFERENCES:
patent: 4772594 (1988-09-01), Hashimoto
patent: 5057523 (1991-10-01), Chu et al.
patent: 5077056 (1991-12-01), Bally et al.
patent: 5192549 (1993-03-01), Barenolz et al.
patent: 5380531 (1995-01-01), Chakrabarti et al.
patent: 5741516 (1998-04-01), Webb
patent: 5785987 (1998-07-01), Hope
Agarwel in J. Med. Chem 33, p. 1505 (1990).
Boman, N.L. et al., "Optimization of the Retention Properties of Vincristine in Liposomal Systems," Biochimica et Biophysica Acta. 1152: 253-258 (1993).
Brossi, A. et al., "1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydr o-4-oxo-3-quinoline-carboxylic Acid. New Quinolone Antibacterial with Potent Gram-Positive Activity," J. Med. Chem. 29: 445-448 (1986).
Culbertson, T.P. et al., "Quinolone Antibacterial Agents Substituted at the 7-Position with Spiroamines. Synthesis and Structure-Activity Relationships," J. Med. Chem. 33: 2270-2275 (1990).
Hagen, S.E. et al., "New Quinolone Antibacterial Agents. Synthesis and Biological Activity of 7-(3,3-or 3,4-Disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic Acids," J. Med. Chem. 33: 849-854 (1990).
Hagen, S.E. et al., "Synthesis and Biological Activity of 5-Alkyl-1,7,8,-trisubstituted-6-fluoroquinoline-3-carboxylic Acids," J. Med. Chem. 34: 1155-1161 (1991).
Klopman, G. et al., "Anti-Mycobacterium avium Activity of Quinolones: In Vitro Activities," Antimicrobial Agents and Chemotherapy. 37:(09) 1799-1806 (1993).
Lasic, D.D. et al., "Gelation of Liposome Interior," FEBS. 312:(02,03) 255-258 (1992).
Madden, T.D. et al., "The Accumulation of Drugs within Large Unilamellar Vesicles Exhibiting a Proton Gradient: A Survey," Chemistry and Physics of Lipids 53: 37-46 (1990).
Renau, T.E. et al., "Structure--Activity Relationships of the Quinolone Antibacterials against Mycobacteria: Effect of Structural Changes at N-1 and C-7," J. Med. Chem. 39: 729-735 (1996).
Sanchez J.P. et al., "Quinolone Antibacterial Agents. Synthesis and Structure--Activity Relationships of 8-Substituted Quinoline-3-carboxylic Acids and 1,8-Naphthyridine-3-carboxylic Acids," J. Med. Chem. 31: 983-991 (1988).
Gittelman Josh
Guo Luke S. S.
Martin Francis J.
Zalipsky Samuel
Kishore Gollamudi S.
Mohr Judy M.
Sequus Pharmaceuticals, Inc.
LandOfFree
Liposome composition and method for administering a quinolone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Liposome composition and method for administering a quinolone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposome composition and method for administering a quinolone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-760995