Liposome composition

Details Liposome composition Liposome composition

1986-11-21

1989-07-04

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 264 46, 424 71, 424 852, 424 943, 4284022, 436829, 514885, A61K 3722, A61K 966, A61K 4505, B01J 1302

Patent

active

048449040

ABSTRACT:
Liposome compositions in which a drug is retained in stable condition are prepared by dispersing liposomes obtained by removal of a solvent from a drug-containing w/o emulsion in an aqueous solution having an osmotic pressure higher by at least 20 percent than the osmotic pressure of a solution used for entrapping the drug in said liposomes. This composition is conducive to a sustained therapeutic efficacy or a better delivery of the drug to a target organ.

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Lenk et al., "Novel Multilayered Lipid Vesicles . . . ", Biochemistry, vol. 24, May 1985, pp. 2833-2842.
Chem. Abstr., vol. 97 (1982), 35016q.
Tsao et al., "Sendai Virus Induced Leakage of Liposomes Containing Gangliosides", Biochemistry, vol. 24, Feb. 1985, pp. 1092-1098.
Lichtenberg et al., "Effect of Surface Curvature on Stability, . . . Single Lamellar Vesicles", Biochemistry, vol. 20, Jun. 1981, pp. 3462-3467.
Chem., Abstr., vol. 100 (1984) 12523u.
Chem. Abstr., vol. 94(1981), 162698b.
Higgins et al., Journal of Pharmacy and Pharmacology, vol. 36, Supplement, 1984, p. 24P.

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