Liposome complexes for increased systemic delivery

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

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C424S417000

Reexamination Certificate

active

07001614

ABSTRACT:
Highly efficient cationic liposomes have been developed as an improved delivery system for biologically-active reagents. A novel structure, the sandwich liposome, is formed and comprises one or more biologically active agents internalized between two bilomellar liposomes. This structure protects the incoming agent and accounts for the high efficiency of in vivo delivery and for the broad tissue distribution of the sandwich liposome complexes.These novel liposomes are also highly efficient carriers of nucleic acids. By using extruded DOTAP:cholesterol liposomes to form complexes with DNA encoding specific proteins, expression has been improved dramatically. Highest expression was achieved in the lung, while increased expression was detected in several organs and tissues.

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B. Sternberg, “Morphology of Cationic Liposome/DNA Complexes in Relation to Their Chemical Compositions,”Journal of Liposome Research, 6(3), pp 515-533 (1996).
T. Kato, et al., “Synthetic Cationic Amphiphile for Liposome-Mediated DNA Transfection with Less Cytotoxicity,”Biol. Pharm. Bull., 19(6), pp. 860-863 (1996).
E. K. Wassan, et al., “Plasmid DNA is Protected Against Ultrasonic Cavitation-Induced Damage When Complexed to Cationic Liposomes,”Journal Pharm. Sciences, 85(4), pp. 427-433 (1996).

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