Liposome carriers in leishmaniasis chemotherapy with 8-aminoquin

Details Liposome carriers in leishmaniasis chemotherapy with 8-aminoquin Liposome carriers in leishmaniasis chemotherapy with 8-aminoquin

1980-03-19

1981-11-24

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424199, 424245, 424365, A61K 3147

Patent

active

043024599

ABSTRACT:
An improved method is provided for the chemotherapy of leishmanial infects. An 8-aminoquinoline anti-leishmanial agent is encapsulated within liposomes and the liposome-encapsulated drug is injected into the body. Subject use of a liposome carrier has produced marked enhancement of the effectiveness of the drug against leishmanial parasites in the liver (such as characteristic of infections which are difficult to treat).

REFERENCES:
patent: 4016290 (1977-04-01), Rahman
patent: 4224179 (1980-09-01), Schneider
Alving et al.--Chem. Abst. vol. 91 (1979) p. 162, 911d.
Alving et al.-Chem. Abst. vol. 89 (1978)pp. 140, 460n.

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