Liposome carriers in chemotherapy of leishmaniasis

Details Liposome carriers in chemotherapy of leishmaniasis Liposome carriers in chemotherapy of leishmaniasis

1978-03-29

1980-01-29

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 19, 424131, 252316, A61K 3324, A61K 950, B01J 1302

Patent

active

041861833

ABSTRACT:
An improved method is provided for the chemotherapy of leishmanial infections. The anti-leishmanial agent is encapsulated within liposomes and the liposome-encapsulated drug is injected into the body. Subject use of a liposome carrier has produced marked enhancement of the effectiveness and duration of anti-leishmanial action of meglumine antimoniate, and of sodium stibogluconate, drugs which are recommended widely for therapy of leishmaniasis.

REFERENCES:
H. Kimelberg, Biochim. et Biophys. Acta, 448 (1976), 531-550.
G. Gregoriadis, N. Eng. J. of Med., 295 (1976) 13, 704-710, The Carrier Pntial of Liposomes in Biology and Medicine.
D. Tyrell et al., Biochim. et Biophys. Acta, 457 (1976), 259-302, New Aspects of Liposomes.
Merck Index 9th Edition (1976), #5945, #739.
R. Neal, Chemical Abstracts, 87: 78360h (1977).
N. Ercoli, Chemical Abstracts 66: 93771c (1967).
J. Mikhail et al., Chemical Abstracts 83: 37724d (1975).

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