Liposomally encapsulated nucleic acids having high entrapment ef

Details Liposomally encapsulated nucleic acids having high entrapment ef Liposomally encapsulated nucleic acids having high entrapment ef

1995-06-07

1998-05-26

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

935 54, A61K 9127

Patent

active

057561222

ABSTRACT:
An improved method for encapsulating high molecular weight nucleic acids in liposomes, which provides for high nucleic acid entrapment efficiencies, is provided. The resulting compositions provide enhanced in vitro and in vivo transfection and are useful, for example, in producing cell lines expressing a desired nucleic acid sequence.

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