Liposomal transfection method

Details Liposomal transfection method Liposomal transfection method

1998-05-21

2000-06-13

Guzo, David

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

435440, 4352523, 43525411, 560224, 554226, A61K 9127

Patent

active

06074667&

ABSTRACT:
An improvement in a method for transfecting a cell with a nucleic acid the improvement comprising contacting the cell with a liposomal transfection composition comprising the nucleic acid, sphingosine or a derivative thereof, having a protonable amino group in the sphingosine moiety, and at least one helper lipid.

REFERENCES:
Singhal et al. Gene Transfer in Mammalian Cells Using Liposomes as Carriers. Gene Therapeutics. Ed. Jon A. Wolff, Mar. 1994.
Koiv et al. Binding of DNA to Liposomes Containing Different Derivatives of Sphingosine. Chem. Phys. Lipids. 72: 77-86, Feb. 1994.
Orkin et al. Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Dec. 1995.

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