Liposomal thermograph and methods for making and using same

Details Liposomal thermograph and methods for making and using same Liposomal thermograph and methods for making and using same

1987-09-21

1989-04-25

Envall, Jr., Roy N.

Thermal measuring and testing

Temperature measurement

Nonelectrical, nonmagnetic, or nonmechanical temperature...

264 41, 374162, 424450, G01K 1100

Patent

active

048254479

ABSTRACT:
A liposomal thermograph is employed to monitor the thermal history of goods in transit or storage. The liposomal thermograph becomes fluorescent if the temperature of the goods exceed an operating range. The liposomal thermograph is bi-directional, i.e. it becomes fluorescent if the temperature transgression either falls below a set value on the lower end of the operating range or if it rises toward the upper end of the operating range. The activation of the liposomal thermograph is abrupt at the lower end of operating range. However, at the upper end of the operating range, the liposomal thermograph displays a ramp effect, i.e. the onset of fluorescence is progressive and depends upon the duration of the transgression and the magnitude. The liposomal thermograph is made from a sachet which is filled with a suspension of liposomes which have been loaded with an amphphilic anionic fluorescent dye, preferably having a sodium counterion. The operating range of the liposomal thermograph is determined at the lower end by the freezing point of the liquid medium in which the liposomes are suspended. At the upper end, the operating range is determined by the transition temperature of the lipid membrane of the liposomes.

REFERENCES:
patent: 3233459 (1966-02-01), Gleason et al.
patent: 4729671 (1988-03-01), Asano
patent: 4743557 (1988-05-01), Tiru et al.

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