Liposomal targeting of ischemic tissue

Details Liposomal targeting of ischemic tissue Liposomal targeting of ischemic tissue

1993-06-25

1996-06-18

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424450, A61K 9127

Patent

active

055275389

ABSTRACT:
Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas in the absence of antibodies bound to the liposomes to effect the delivery.

REFERENCES:
patent: 4728575 (1988-03-01), Gamble et al.
patent: 4753788 (1988-05-01), Gamble
patent: 4873088 (1989-10-01), Mayhew
patent: 4976964 (1990-12-01), Schlossmann
patent: 5019369 (1991-05-01), Presant et al.
Proffitt et al. J. Nuclear Medicine 24, #1, 1983, p. 45.
Gregoriadis & Senior. FEBS Letters 119, p. 43, 1980.
Caride et al Science, 198, p. 735 1977.
Mueller et al, Circulation research 49, 405, 1981.
Cole et al., Cardiovascular Research 16, 516-523 (1982).
Chemical Abstracts, vol. 109, No. 11, 12 Sep. 1988, Columbus, Ohio, US; abstract No. 85657M, D. Zang et al.: `the distribution of liposome-encapsulated atp in experimental ishmeic myocardium` p. 11; columb 2; &zhonghua xinxeuquanbing zazhi 1988, 16(1). 48-51 (abstract).
Chemical Abstracts, vol. 112, No. 6, 5 Feb. 1990, Columbus Ohio, US; abstract No. 42426E, S. Chapat et al.: `variations of the plasma concentration of adenosine triphosphate (atp) in experimental cerebral ischemia after the intra-carotid administration of atip liposomes` p. 432; column 2; &congr. int. technol. pharm., 5th 1989, 3 66-71 (the abstract).
Chemical Abstracts, vol. 100, No. 17, 23 Apr. 1984, Columbus, Ohio, US; abstract No. 136841R, T. N. Palmer, `the mechanisms of liposome accumulation in infarction` p. 459; column 1; &biochim, biophys. acta 1984, 797(3), 363-8 (abstract).
Supplementary European Search Report; 02 Apr. 1992 (pp. 1-2). EP90907986.
Caride & Sostman, "Methodological Considerations for the Use of Liposomes in Diagnostic Imaging" Chap. 8 in Liposome Technology vol. II (1984) pp. 108-124.
Tumor-Imaging Potential of Liposomes Loaded with In-111-NTA: Biodistribution in Mice, Proffitt et al. 1983) J. Nucl. Med. 24, 45-51.
Liposomal Blockade of the Reticuloendothelial System: Improved Tumor Imaging with Small Unilamellar Vesicles, Proffitt et al. (1983) Science 220, 502-505.
Caride & Sostman, "Methodological Considerations for the Use of Liposomes in Diagnostic Imaging" Chap. 8 in Liposome Technology vol. II (1984) pp. 108-124.
Caride et al., Science 198, 735-738 (1977).
Mueller et al., Circulation Research 49, 405-415 (1981).
Cole et al., Cardiovascular REsearch 16, 516-523 (1982).
Leinberger et al., Microcirculation of the Heart, Springer-Verlag 98-103 (1982).
Palmer et al., Bioscience Reports I, 337-344 (1981).
Caride, Adv. Cardiol. 27, 114-126 (1980).
Caride et al., J. Cardiovascular Pharmacology 6, 996-1005 (1984).
Caride et al., Clin. Res. 26, 223A (1978).
Goldman et al., J. Comput. Assist. Tomogr. 5, No. 2 (1981).
Jennings et al., Microcirculation of the Heart, Springer-Verlag 87-97 (1982).

Affiliated with

Also associated with

Rating

Liposomal targeting of ischemic tissue does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Liposomal targeting of ischemic tissue, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposomal targeting of ischemic tissue will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-221205