Liposomal products

Details Liposomal products Liposomal products

1995-03-23

2000-05-09

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, A61K 9127

Patent

active

060600802

ABSTRACT:
A liposomal aqueous dispersion and method of making the liposomal aqueous dispersion is useful for encapsulation of drugs. The liposomal aqueous dispersion comprises: an aqueous suspension medium; multilamellar liposomes comprising an anionic phospholipid and cholesterol as essential components; neutral phospholipid in a mole ratio of 0 to 40% based on the total amount of said multilamellar liposomes; and a cation moiety-containing water-soluble drug, wherein the electrolyte concentration of said aqueous suspension medium is not more than 40 mM.

REFERENCES:
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patent: 4756910 (1988-07-01), Yagi et al.
patent: 4769250 (1988-09-01), Forssen
patent: 4818537 (1989-04-01), Guo
patent: 4830858 (1989-05-01), Payne
patent: 4873088 (1989-10-01), Mayhew
patent: 4906477 (1990-03-01), Kurono et al.
patent: 4927571 (1990-05-01), Huang et al.
Grant & Hackh's Chemical dictionary. 1987. p. 205.
P. Buri et al. "Formes Pharmaceutiques Nouvelles", 1985, Technique et Documentation (Lavoisier), Paris FR, pp. 470 and 484.

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