Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1999-08-03
2000-08-01
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514283, A61K 948, A61K 3144
Patent
active
060963360
ABSTRACT:
Liposomal prodrugs include specific derivatives of camptothecin restrained by a liposomal delivery system. The derivatives of camptothecin are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.4 alkyl group, a C.sub.6 -C.sub.15 alkyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a C.sub.2 -C.sub.15 alkenyl group or a C.sub.2 -C.sub.15 epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.2 -C.sub.15 alkenyl group, a C.sub.3 -C.sub.8 cycloalkyl group, or an epoxy group. Processes for making these prodrugs and for using them in cancer treatment are also disclosed.
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Cao Zhisong
Giovanella Beppino C.
Lambkin Deborah C.
The Stehlin Foundation for Cancer Research
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