Liposomal-polyene preliposomal powder and method for its prepara

Details Liposomal-polyene preliposomal powder and method for its prepara Liposomal-polyene preliposomal powder and method for its prepara

1991-01-14

1993-01-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 4284022, 42840221, A61K 3722

Patent

active

051788756

ABSTRACT:
A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.

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