Liposomal-polyene preliposomal powder and method for its prepara

Details Liposomal-polyene preliposomal powder and method for its prepara Liposomal-polyene preliposomal powder and method for its prepara

1997-11-26

1999-10-12

Kishore, Gollemudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424489, 424498, 264 41, 264 43, 4284022, A61K 9127

Patent

active

059651580

ABSTRACT:
A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.

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