Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonu

Details Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonu Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonu

1995-08-29

1999-01-05

LeGuyader, John L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

435 6, 435 911, 536 231, 536 243, 536 245, 514 44, C12Q 168, C07H 2102, C07H 2104, A01K 9127

Patent

active

058559116

ABSTRACT:
An improved delivery system for antisense oligonucleotides involves a liposomal composition, comprising a liposome which consists essentially of neutral phospholipids and an antisense oligonucleotide that is entrapped in the liposome and is selected from the group consisting of phosphodiester oligonucleotides, phosphorothioate oligonucleotides, and p-ethoxy oligonucleotides.

REFERENCES:
patent: 4480041 (1984-10-01), Myles et al.
patent: 4721612 (1988-01-01), Janoff et al.
patent: 4924624 (1990-05-01), Suhadolnik et al.
patent: 4950432 (1990-08-01), Mehta et al.
patent: 5030442 (1991-07-01), Uster et al.
patent: 5049388 (1991-09-01), Knight et al.
patent: 5087617 (1992-02-01), Smith
patent: 5098890 (1992-03-01), Gewirtz et al.
patent: 5100662 (1992-03-01), Bolcsak et al.
patent: 5112962 (1992-05-01), Letsinger et al.
patent: 5135917 (1992-08-01), Burch
patent: 5178875 (1993-01-01), Lenk et al.
patent: 5188897 (1993-02-01), Suhadolnik et al.
patent: 5227170 (1993-07-01), Sullivan
patent: 5248671 (1993-09-01), Smith
patent: 5264618 (1993-11-01), Felgner et al.
patent: 5271941 (1993-12-01), Cho-Chung
patent: 5279957 (1994-01-01), Gross
patent: 5320962 (1994-06-01), Stiles et al.
patent: 5324654 (1994-06-01), Bredesen
patent: 5417978 (1995-05-01), Tari et al.
Wu-Pong, Oligonucleotides: Opportunities for Drug Therapy and Research, Pharmaceutical Technology, vol. 18, Oct. 1984, pp. 102-114.
Gura, Antisense Has Growing Pains, Science, vol. 270, Oct. 1995, pp. 575-577.
Stein et al., Antisense Oligonucleotides as Therapeutic Agents--Is the Bullet Really Magical?, Science, vol. 261, Aug. 1993, pp. 1004-1012.
Wagner, Gene inhibition using antisense oligodeoxynucleotides, Nature, vol. 372, Nov. 1994, pp. 333-335.
Stull et al., Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects, Pharmaceutical Research, vol. 12, No. 4, 1995, pp. 465-483.
Thierry et al., Liposomal Delivery as a New Approach to Transport Antisense Oligonucleotides, Gene Regulation Biology of Antisense RNA and DNA, vol. 1, 1992, pp. 147-161.
Miller et al., Gene Transfer and Antisense Nucleic Acid Techniques, Parasitology Today, vol. 10, No. 3, 1994, pp. 92-97.
Rojanasakul, Antisense oligonucleotide therapeutics: drug delivery and targeting, Advanced Drug Delivery Reviews, vol. 18, 1996, pp. 115-131.
Weis, Upping the Antisense Ante Scientists bet on profits from reverse genetics, Science News, vol. 139, 1991, pp. 108-109.
Uhlmann et al., Antisense oligonucleotides: a new therapeutic principal, Chemical Reviews, vol. 90(4), pp. 543-584, Jun. 1990.
Akhtar et al., "Interactions of Antisense DNA Oligonucleotide Analogs with Phospholipid Membranes (Liposomes)", Nucleic Acids Research, 19(20): 5551-5559 (Oct. 25, 1991).
Thierry et al., "Liposomal Delivery as a New Approach to Transport Antisense Oligonucleotides", Gene Regulation, Biology of Antisense RNA and DNA, 1: 147-161 (1992).
Theirry et al., "Intracellular Availability of Unmodified, Phosphorothioated and Liposomally Encapsulated Oligodeoxynucleotides for Antisense Activity", Nucleic Acids Research, 20(21):5691-5698 (Sep. 28, 1992).
Ropert et al., "Inhibition of the Friend Retrovirus by Antisense Oligonucleotides Encapsulated in Liposomes: Mechanism Action", Pharmaceutical Research, 10(10): 1427-1433 (Apr. 5, 1993).
Tari et al., "Liposomal Delivery of Methylphosphonate Antisense Oligodeoxynucleotides in Chronic Myelogenous Leukemia", Blood, 84(2): 601-607 (Jul. 15, 1994).
Akhtar et al., "Liposome Delivery of Antisense Methylphosphonate and Phosphorothioate Oligonucleotides: A Study with MLV, FATMLV, AND LUV Liposomes", Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 19: 345-346 (1992).
Akhtar et al., "Release of Antisense Oligdeoxynucleotide Analogues from Liposomes: Implications for Cellular Transport and Drug Delivery", 128th Meeting of British Pharmaceutical Conference 1991, UK, 9/10-13/91, J. Pharm. Pharmacol. 43 (Suppl.) 1991, Abstract 24 P.
Thierry et al., "Overcoming Multidrug Resistance in Human Tumor Cells Using Free and Liposomally Encapsulated Antisense Oligodeoxynucleotides", Biochemical and Biophysical Research Communications, 190(3): 952-960 (Feb. 15, 1993).
Citro et al., "Chemical Modification of Ligands for Cell Receptors to Introduce Foreign Compounds into the Cells", Colon & Rectum, 37(2): S127-132 (Feb. 1994).
Clarenc et al., "Delivery of Antisense Oligonucleotides by poly(L-lysine) Conjugation and Liposome Encapsulation", Anti-Cancer Drug Design, No. 8: 81-94 (1993).
Loke et al., "Delivery of c-myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic Cells in culture by Liposome Fusion: Specific Reduction in c-myc Protein Expression Correlates with Inhibition of Cell Growth and DNA Synthesis", Current Topics in Microbiology and Immunology, Mechanisms in B-Cell Neoplasia, 141: 282-289 (1988).
Stein et al., "Oligodeoxynucleotides as Inhibitors of Gene Expression: A Review", Cancer Research, 48(10): 2635-2944 (May 15, 1988).
Tsuchida et al., "Iron-Ligand Bonding Properties of Synthetic Iron-Porphyrin Complexes with Oxygen Transporting Ability in Aqueous Media", J. Chem. Soc. Dalton Transactions, No. 10: 2455-2458 (Oct 1987).
Arad et al., "Use of Reconstituted Sendai Virus Envelopes for Fusion-Mediated Microinjection of Double-Stranded RNA: Inhibition of Protein Synthesis in Interferon-Treated Cells", Biochimica et Biophysica Acta, 859: 88-94 (1986).
Agris et al., "Inhibition of Vesicular Stomatitis Virus Protein Synthesis and Infection by Sequence-Specific Oligodeoxyribonucleoside methylposphonates", Biochemistry, 25: 6268-6275 (1986).
Martiat et al., "Retrovirally Transduced Antisense Sequences Stably Suppress P210.sup.BCR-ABL Expression and Inhibit the Proliferation of BCR/SBL-Containing Cell Lines", Blood, 81(2): 502-509 (Jan. 15, 1993).
Taj et al., "Inhibition of P210.sup.BCR/ABL Expression in K562 Cells by Electroporation with an Antisense Oligonucleotide", Leukemia and Lymphoma, 3: 201-208 (May 19, 1990).
Szczylik et al., "Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides", Science, 253: 562-565 (Aug. 2, 1991).
Tidd et al., "Evaluation of N-ras Oncogene Anti-sense, Sense and Nonsense Sequence methylphosphonate Oligonucleotide Analogues", Anti-Cancer Drug Design, 3: 117-127 (1988).
Tidd et al., "Partial Protection of Oncogene, Anti-sense Oligodeoxynucleotides Against Serum Nuclease Degradation Using Terminal Methylphosphonate Groups", Be. J. Cancer, 60: 343-350 (1989).
Moody et al., "Regiospecific Inhibition of DNA Duplication by Antisense Phosphate-Methylated Oligodeoxynucleotides", Nucleic Acids Research, Abstract, 17(12): 4769-4782 (May 15, 1989).
Loke et al., "Delivery of c-myc Antisense Oligodeoxynucleotides to Hematopoietic Cells in Culture by Liposome Fusion: Specific Reduction in c-myc Protein Expression Corelates with Inhibition of Cell Growth and DNA Synthesis", Clinical Research, AFCR Immunology Abstract, 36(3): 443A (1988).
Vasanthakumar et al., "Modulation of Drug Resistance in a Daunorubicin Resistant Subline with Oligonucleoside Methylphosphonates", Cancer Communications, 1(4): 225-232 (1989).
Leonetti et al., "Antibody-targeted Liposomes Containing Oligodeoxyribonucleotides Complementary to Viral RNA Selectively Inhibit Viral Replication," Proc. Natl. Acad. Sci. USA, 87: 2448-2451 (Apr. 1990).
Renneisen et al., "Inhibition of Expression of Human Immunodeficiency Virus-1 in Vitro by Antibody-targeted Liposomes Containing Antisense RNA to the env Region", The Journal of Biological Chemistry, 265(27): 16337-16342 (1990).
Boiziau et al., "Modified Oligonucleotides in Rabbit Reticulocytes: Uptake, Stability and Antisense Properties", Biochimie, 73: 1403-1408 (1991).
Miller, "Oligonucleoside Methylphosphonates as Antisense Reagents", Bio/Technology, 9: 358-362 (Apr. 1991).
Thierry et al., "Modulation of Multidrug Resistance by Antisense Oligodeoxynucleotides Encapsulated by Liposomes", Proceedings of the American Association for Cancer Research, Preclinical Pharmacology/Experimental Therapeutics, Abstracts 2578, 32: 433 (Mar. 1991).
Juliano et al., "Liposomes

Affiliated with

Also associated with

Rating

Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-859867