Liposomal influenza vaccine composition and method

Details Liposomal influenza vaccine composition and method Liposomal influenza vaccine composition and method

1997-06-23

1999-07-06

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4242061, 436829, A61K 9127

Patent

active

059194804

ABSTRACT:
Subunit influenza vaccines containing an influenza H/N antigen and a cytokine immunopotentiator, where at least one and preferably both are encapsulated in liposomes, are described. The vaccines stimulate a strong humoral and CTL response. Also described are methods of immunization using such vaccines.

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Kedar, E. et al, "Delivery of Cytokines by Liposomes. I. Preparation and Characterization of Interleukin-2 Encapsulated in Long-Circulating Sterically Stabilized Liposomes," Journal of Immunotherapy. 16:(1) 47-59 (1994).
Mbawuike, I.N. et al., "Enhancement of the Protective Efficacy of Inactivated Influenza A Virus Vaccine in Aged Mice by IL-2Liposomes," Vaccine. 8:347-352 (1990).
Iinuma, H. et al., "Characteristics of Cytotoxic T Lymphocytes Directed to Influenza Virus Haemagglutinin Elicited by Immunization with Muramyldipeptide-Influenza Liposome Vaccine," Scand. J. Immunol. 41:1-10 (1995).
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