Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2008-04-08
2008-04-08
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C424S489000
Reexamination Certificate
active
11298729
ABSTRACT:
Pharmaceutical liposomal formulations are described for photodynamic therapy comprising a, hydrophobic porphyrin photosensitizer, a monosaccharide and one or more synthetic phospholipids, which are stable in storage especially through freeze-drying process. The liposomal formulations provide therapeutically effective amounts of the photosensitizer for intravenous administration. In particular derivatives of chlorins and bacteriochlorins, such as temoporfin, are, hydrophobic photosensitizers whose efficacy and safety are enhanced by such liposomal formulations. The formulation can be efficiently freeze-dried preserving the size of the liposomal vehicles, and the content of a therapeutically effective amount of the photosensitizer, due to the selection of phospholipids and monosaccharides. The invention also relates to liposome compositions formed upon reconstitution with an aqueous vehicle. The freeze-dried formulation upon reconstitution with a suitable aqueous vehicle forms liposomes that are useful for intravenous administration.
REFERENCES:
patent: 5190761 (1993-03-01), Liburdy
patent: 5389378 (1995-02-01), Madden
patent: 5773027 (1998-06-01), Bergeron et al.
patent: 6074666 (2000-06-01), Desai et al.
patent: 6440950 (2002-08-01), Zeimer
patent: 6498945 (2002-12-01), Alfheim et al.
patent: 2005/0107329 (2005-05-01), Desai et al.
Harris and Chess, “Effect of Peguylation on Pharmaceuticals,” Nature, Mar. 2003, vol. 2, pp. 214-221.
Mody, “Pharmaceutical development and medical applications of porphyrin-type macrocycles,” Journal of Porphyrins and Phth. Vo. 4, 362-367.
Storn and Crommelin, “Liposomes: quo vadis?” PSTT, vol. 1, No. 1, Apr. 1998, 19 to 31.
Albrecht Volker
Fahr Alfred
Gräfe Susanna
Neuberger Wolfgang
Scheglmann Dietrich
B J Associates
CeramOptec Industries Inc.
Kishore Gollamudi S.
Skutnik Bolesh J.
LandOfFree
Liposomal formulations of hydrophobic photosensitizer for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Liposomal formulations of hydrophobic photosensitizer for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposomal formulations of hydrophobic photosensitizer for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3942039