Liposomal formulation

Details Liposomal formulation Liposomal formulation

1995-06-07

1998-10-13

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4241841, 4242771, 4242781, 4242831, 436829, 514 2, 514885, 514964, A61K 9127, A61K 3306, A61K 39385, A61K 966

Patent

active

058208801

ABSTRACT:
Depending on the antigen encapsulated, liposomal formulations are subject to instability in the presence of alum. Formulations containing a nonionic detergent as a stabilizing agent avoid this instability.

REFERENCES:
patent: 4897269 (1990-01-01), Mezei
patent: 5013555 (1991-05-01), Collins
patent: 5053217 (1991-10-01), Lehigh
patent: 5374548 (1994-12-01), Caras
White, W.I., et al., "Antibody and cytotoxic T-lymphocyte responses to a gle liposome-associated peptide antigen," Vaccine (1995) 13(12):1111-1122 .

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