Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1991-09-09
1994-01-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424417, 4284022, 436829, A61K 9127
Patent
active
052779130
ABSTRACT:
A triggered release liposomal delivery system is disclosed that selectively releases its contents in response to illumination or reduction in pH. The liposomes contain an amphipathic lipid, such as a phospholipid, having two chains derived from fatty acid that allow the lipid to pack into a bilayer structure. One or both of the alkyl chains contains a vinyl ether functionality that is cleaved by reactive oxygen species (ROS) or acid. A photosensitizer is incorporated into the liposomal cavity or membrane, and produces ROS or acid when illuminated to cleave the vinyl ether functionality and disrupt the liposomal membrane to release the vesicle contents. The lipid is preferably a plasmalogen, for example ##STR1## wherein R.sub.1 and R.sub.2 are each long chain hydrocarbons containing 12-24 carbons.
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Anderson Valerie C.
Thompson David H.
Kishore G. S.
Page Thurman K.
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