Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-04-05
1997-11-04
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
A61K 9127
Patent
active
056837143
ABSTRACT:
An improved liposomal cyclosporin therapeutic formulation, comprising phosphatidylcholine, phosphatidylglycerol and a cyclosporin in a mole ratio of from 25:3:1 to 17:3:1 is described. The formulation includes unilamellar vesicles having reduced toxicity. The formulation is used as an immunosuppressive agent and is an enhancer of the efficacy of antineoplasties for drug resistant cancer cells. A method is also provided for inhibiting the growth of cancer cells.
REFERENCES:
patent: 4608211 (1986-08-01), Handjani et al.
patent: 4663167 (1987-05-01), Berestein
patent: 4692433 (1987-09-01), Hostetler
patent: 4797285 (1989-01-01), Barenholz et al.
patent: 4812312 (1989-03-01), Lopez-Berestein et al.
patent: 4895719 (1990-01-01), Radhakrishan et al.
patent: 4913902 (1990-04-01), Kilpatrick et al.
patent: 4952405 (1990-08-01), Young
patent: 4963362 (1990-10-01), Rahman
patent: 5000887 (1991-03-01), Tenzel et al.
patent: 5023087 (1991-06-01), Young
Szoka Ann. Rev. Biophys. Bioeng. 1980. 9, p. 467.
Venkataan. J. Pharm. Sciences 79, #3, Mar. 1990.
Deamer. Liposome Prep. Chap I, 1983 p. 27.
Gilbert et al., Characterization and Administration of Cyclosporin Liposomes as a Small-Particle Aerosol, Chemical Abstracts, vol. 120, No. 14, 4 Apr. 1994, Columbus, Ohio, US, Abstract No. 173337q.
Van de Vrie, W., "In vitro and in vivo chemosensitizing effect of cyclosproin A on an intrinsic multidruresistant rat colon tumour", Cancer Research Clinical Oncology vol. 119, pp. 609-614 (1993).
Freise, Chris E., "The Increased efficacy and decreased nephrotoxicity of a cyclosporine liposome", Transplantation vol. 57, No. 6, pp. 928-932 (Mar. 1994).
Sonneveld, P, "Clinical modulation of multidrug resistance in multiple myeloma: Effect of cyclosporin on resistant tumor cells", Journal of Clinical Oncology vol. 12, No. 8, pp. 1584-1591 (Aug. 1994).
Colombo, Tina, "Cyclosporin a markedly changes the distribution of doxorubicin in mice and rats", The Journal of Pharmacology and Experimental therapeutics, vol. 269, No. 1, pp. 22-27 (1994).
Yano, Seiji, "Cyclosporin a enhances susceptibility of multi-drug resistant human cancer cells to anti P-glycoprotein antibody-dependent cytotxicity of monocytes, but not of lymphocytes", J. Cancer Re vol. 85, pp. 194-203 (Feb. 1994).
van der Graaf, Winette T.A., "Effects of amiodarone, cyclosporin A, and PSC 833 on the cytotoxicity of mitoxantrone, doxorubicin and vincristine in non-P-glycoprotein human small cell lung cancer cell lines", Cancer Research vol. 54, pp. 5368-5373 (Oct. 15, 1994).
Erlichman, Charles, "Phase I pharmacokinetic study of cyclosporin a combined with doxorubicin", Cancer Research vol. 53, pp. 4837-4842 (Oct. 15, 1983).
Sonneveld, Pieter, "Modulation of multidrug-resistant multiple myeloma by cyclosporin", The Lance vol. 340, No. 8814, pp. 255-259 (Aug. 1, 1992).
Samuels, Brian L., "Modulation of vinblastine resistance with cyclosporine: A phase I study", Clinic Pharmacology & Therapeutics vol. 54, No. 4, pp. 421-429 (Oct. 1993).
Sikic, Branimir I., "Modulation of multidrug-resistance: At the Threshold", Journal of clinical Onocolog vol. 11, No. 9, pp. 1629-1635 (Sep. 1993).
Thierry, Alain R., "Effect of liposomes on P-glycoprotein function in multidrug-resistant cells", Biochemical and Biophysical Research Communications vol. 187, No. 2, pp. 1098-1105 (Sep. 16 1992).
Rahman, Aquilur, "Liposome-mediated modulation of multidrug resistance in human HL-60 leukemia cells", Journal of the National Cancer Institute vol. 84, No. 24, pp. 1909-1915 (Dec. 16, 1992).
Dalton, William S., "Drug resistance modulation in the laboratory and the clinic", Seminars in Oncology vol. 20, No. 1, pp. 64-69 (Feb. 1993).
Clynes, Martin, "Cellular models for multiple drug resistance in cancer", In Vitro Cell. Dev. Biol. 29A, pp. 171-179 (Mar. 1993).
Dietel, Manfred, "Second International symposium on cytostatic drug resistance", Cancer Research vol. 53, pp. 2683-2688 (Jun. 1, 1993).
Twentyman, Peter R., "A possible role for cyclosporins in cancer chemotherapy", Anticancer Researc vol. 8, pp. 985-994 (1988).
List, Alan F., "Phase I/II trial of cycloporine as a chemotherapy resistance modifier in acute leukemia", Journal of Clinical Oncology vol. 11, No. 9, pp. 1652-1660 (Sep. 1993).
Boesch, Danielle,"In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833", Cancer Research vol. 51, pp. 4226-4233 (Aug. 15, 1991).
Yahanda, Anne M., "Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance", Journal of Clinical Onocology vol. 10, No. 10, pp. 1624-1634 (Oct. 1992).
Benedicte Jachez, Rene, "Restoration of taxol sensitivity of multidrug resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446", Journal of the National cancer Institute vol. 85, No. 6, pp. 478-483 (Mar. 17, 1993).
Slater, Lewis M., "Cyclosporin a reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro", Cyclosporin A Corrects Vincristine and Daunorubicin Resistance vol 77, pp. 1405-1408 (Apr. 1986).
Friche, Ellen, "Comparison of cyclosporin A and SDZ PSC 833 as multidrug resistance modulators i a daunorubicin resistant Ehrlich ascites tumor", Cancer Chemotherapy and Pharmacology vol. 30, pp. 235-237 (1992).
Shoji, Y, "Verapamil and cyclosporin A modulate doxorubicin toxicity by distinct mechanisms", Cancer Letters vol. 57, pp. 209-218 (1991).
Hu, Xiu F., "Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines", Cancer Research vol. 50, pp. 2953-2957 (May 15, 1990).
Meador, Josephine,"Enhancement by cyclosporin A of daunorubicin efficacy in Ehrillich ascites carcinoma and murine hepatoma 129", Cancer Research vol. 47, pp. 6216-6219 (Dec. 1, 1987).
Kuhl, Jorn-Sven, "Use of etoposide in combination with cyclosporine for purging multidrug resistant leukemic cells from bone marrow in a mouse model". Advances in Bone Marrow Purgin and Processing, pp. 25-34 (1992).
Nygren, P."Verapamil and cyclosporin a sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca.sup.2+ concentration", Bioscience Reports vol. 10, No. 2, pp. 231-237, (1990).
Twentyman, P.R., "Chemosensitisantion by verapamil nd cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (Sorcin)", Cancer vol. 62, pp. 89-95 (1990).
Saeki, Tohru, "Human P-glycoprotein transports cycloporin A and FK506", the Journal of Biological Chemistry vol. 268, No. 9, pp. 6077-6080 (Mar. 25, 1993).
Hsieh et al. "Preliminary Report: The Use of Liposome-Encapsulated Cyclosporine In a Rat Model", Transplantation Proceedings, vol. XVII, Feb. 1985, 1397-1400.
Stuhne-Sekalec et al. "Encapsulation fo Cyclosporine by Phosphatidylinositol-Cholesterol Liposomes", Transplantation 41, 659-660, 1986.
Stuhne-Sekalec et al. "Co-encapsulation of Cyclosporin and Insulin by Lipo-somes", J. Biochem. Biophys. Methods 13, 23-27, 1986.
Gruber et al. "Liposomal Formulation Eliminates Acute Toxicity and Pump Incompatibility of Parenteral Cyclosporine", Pharm. Res. 6, 601-607, 1989.
Stuhne-Sekalec et al. "Liposomes as Cyclosporin A Carriers: Positively Charged . . . Phosphatidylinositol", J.Microencapsulation 6, 177-182, 1989.
Venkatarum et al. "Pharmacokinetics of Two Alternative Dosage Forms Cyclosporine: Liposomes and Intralipid" J. Pharm. Sci. 79, 216-219, 1990.
Stuhne-Sekalec et al. "Liposomes as Cyclosporin A Carriers: The Influence . . . Cyclosporin A", J. Microencapsulation 8, 283-294, 1991.
Stuhne-Sekalec et al. "Liposomes as Carriers of Cyclosporin A", J. Microen-capsulation 8, 441-446, 1991.
Stuhne-Sekalec et al. "Liposomes as Cyclosporin A Carriers: ESR Study . . . Phosphatidylglycerol Liposomes", J. Microencapsulation 8, 455-463, 1991.
Adler-Moore Jill P.
Chiang Su-Ming
Kishore Gollamudi S.
NeXstar Pharmaceuticals, Inc.
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