Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1993-12-22
1997-01-21
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 41, 264 43, A61K 9127
Patent
active
055957560
ABSTRACT:
Liposomal compositions encapsulating bioactive agents and having improved circulation longevity of the agents are disclosed. Such liposomes combine a low pH of the solution in which a bioactive agent is entrapped and a sugar-modified lipid or an amine-bearing lipid, the combination of which enhances the retention of the encapsulated bioactive agent and thereby promotes circulation longevity. The present invention also discloses methods of making and using such compositions.
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Bally Marcel B.
Boman Nancy L.
Cullis Pieter R.
Mayer Lawrence D.
Inex Pharmaceuticals Corporation
Kishore Gollamudi S.
University of British of Columbia
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