Liposomal bupivacaine compositions prepared using an ammonium su

Details Liposomal bupivacaine compositions prepared using an ammonium su Liposomal bupivacaine compositions prepared using an ammonium su

1999-08-11

2000-12-19

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, A61K 9127

Patent

active

061624624

ABSTRACT:
Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising `GMV` (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.

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