Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2001-06-06
2004-02-10
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C264S004100, C264S004300, C514S248000
Reexamination Certificate
active
06689381
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to liposomal formulations containing benzoquinazoline thymidylate synthase inhibitors. Further, this invention relates to methods of manufacturing and of using such formulations.
BACKGROUND OF THE INVENTION
Liposomes are microscopic vesicles made, in part, from phospholipids which form closed, fluid-filled spheres when dispersed with water. A class of compounds, known as benzoquinazoline thymidylate synthase inhibitors, are known to have antitumor activity (U.S. Pat. No. 5,663,377). Described herein are liposomal formulations containing benzoquinazoline thymidylate synthase inhibitors.
SUMMARY OF THE INVENTION
The present invention provides for liposomal formulations comprising at least one phosphatidylcholine, a cholesterol, and a benzoquinazoline thymidylate synthase inhibitor.
REFERENCES:
patent: 4753788 (1988-06-01), Gamble
patent: 4755388 (1988-07-01), Heath
patent: 4963367 (1990-10-01), Ecanow
patent: 5663337 (1997-09-01), Pendergast et al.
PCT International Search Report for PCT International Application No. PCT/US01/18224 (Exhibit 3).
Ashvar Claudine S.
Chiang Su-Ming
Emerson David L.
Hu Ning
Jensen Gerard M.
Cooper & Dunham LLP
Kishore Gollamudi S.
OSI Pharmaceuticals, Inc.
White John P.
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