Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2008-04-15
2008-04-15
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
Reexamination Certificate
active
10771305
ABSTRACT:
Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
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Barenholz Yechezkel
Bolotin Elijah M.
Grant Gilbert J.
Piskoun Boris
Turndorf Herman
Browdy and Neimark
Kishore Gollamudi S.
New York University
Yissum Research Development, Co
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