Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2008-04-15
2008-04-15
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
Reexamination Certificate
active
07357944
ABSTRACT:
Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
REFERENCES:
patent: 4532089 (1985-07-01), MacDonald
patent: 4937078 (1990-06-01), Mezei et al.
patent: 5188837 (1993-02-01), Domb
patent: 5192549 (1993-03-01), Barenolz et al.
patent: 5244678 (1993-09-01), Legros et al.
patent: 5316771 (1994-05-01), Barenholz et al.
patent: 5356633 (1994-10-01), Woodle et al.
patent: 5612057 (1997-03-01), Lanza et al.
patent: 5723137 (1998-03-01), Wahle et al.
patent: 5807572 (1998-09-01), Kim et al.
patent: 5931809 (1999-08-01), Gruber et al.
patent: 6696080 (2004-02-01), Bolotin et al.
patent: 0 233 100 (1987-08-01), None
patent: 0 361 894 (1990-04-01), None
patent: 9814171 (1998-04-01), None
Antimisiaris et al., “Liposomes as vaccine carriers Incorporation of soluble and particulate antigens in giant vesicles”,Journal of Immunological Methods, (1993), vol. 166, pp. 271-280.
Masters et al., “Liposphere Local Anesthetic Timed-Released for perineural Site Application”,Pharmaceutical Research, (1998), vol. 15, No. 7, pp. 1038-1045.
Mayer et al., “Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles”,Biochimica et Biophysica Acta, (1985), vol. 817, pp. 193-196.
Mowat et al., “Liposonnal Bupivacaine, Extended Duration Nerve Blockage Using Large Unilamellar Vesicles that Exhibit a Proton Gradient”,Anesthesiology, (1996), vol. 85, pp. 635-643.
Turski et al., “Magnetic Resonance Imaging of Rabbit Brain after Intracarotid Injection of Large Multivesocular Lipsomes Containing Paramagnetic Metals and DTPA”,Magnetic Resonance in Medicine, (1988), vol. 7, pp. 184-196.
Pick, “Liposomes with a Large Trapping Capacity prepared by Freezing and Thawing of Sonicated Phospholipid Mixtures”,Archives of Biochemistry and Biophysics, (1981), vol. 212, No. 1, pp. 186-194.
Abstract of Boogaerts, et al., “Plasma concentrations of bupivacaine after brachial plexus administration of liposome-associated and plain solutions to rabbits.”Can. J. Anaesth. 40(12):1201-1204 (1993).
Abstract of Grant, et al., “Prolonged analgesia with liposomal bupivacaine in a mouse model.”Reg. Anesth. 19(4):264-269 (1994).
Haran, et al., “Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases.”Biochimia et Biophysica Acta1151:201-215 (1993).
Weiner, Drug Development and Industrial pharmacy, 15, (10), pp. 1523-1554, 1989.
Stewart, John, “Colorimetric Determination of Phospholipids with Ammonium Ferrothiocyanate”, Analytical Biochemistry, vol. 104, 1980, pp. 10-14.
Barenholz Yechezkel
Bolotin Elijah M.
Grant Gilbert J.
Piskoun Boris
Turndorf Herman
Browdy and Neimark
Kishore Gollamudi S.
New York University
Yissum Research Development, Co
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