Liposomak compositions and methods of preparation

Details Liposomak compositions and methods of preparation Liposomak compositions and methods of preparation

2005-08-09

2005-08-09

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C264S004100, C264S004300, C264S004600, C424S417000

Reexamination Certificate

active

06926905

ABSTRACT:
Long-term local anesthesia is provided by administering to a subject in need thereof a liposomal anesthetic formulation prepared by the dehydration-rehydration method. In this method, lyophilized liposomes encapsulating the local anesthetic are rehydrated by agitating them in an aqueous medium. Preferably this method includes the further step of washing the rehydrated liposomes in hyperosmotic saline solution.

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patent: 0561424 (1993-09-01), None
patent: WO 9742936 (1997-11-01), None
Stewart, James C.M., Colorimetric Determination of Phospholipids with Ammonium Ferrothicyanate, Analytical Biochemistry, May 1, 1980, pp. 10-14. PMID: 6892980 [PubMed—Indexed for MEDLINE].
Bartlett, Grant R., Phosphorus assay in Column Chromatography, Aug. 4, 1958, J. Biol. Chem., 234, pp. 466-468.
Kirby in Biotechnology, Nov. 1984, pp. 979-984.

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