Liposoluble platinum (II) complex and preparation thereof

Details Liposoluble platinum (II) complex and preparation thereof Liposoluble platinum (II) complex and preparation thereof

1988-02-18

1989-11-14

Doll, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

556137, A61K 3128

Patent

active

048808326

ABSTRACT:
New delivatives of platinum (IT) complex which are liposoluble and applicable as antibacterial agents or anticancer agents specific to the affected parts of patients and selectively transferred to the parts when they are used in combination with lipidol, the delivatives being represented by the general formula of: ##STR1## (wherein R.sub.1 and R.sub.2 each stands for a ligand ammine which may have an organic substituent or may be bonded to each other through a bivalent organic group and R.sub.3 represents a bile acid residue). These delivatives being prepared by nitrifying a cis-dichloro-di-(substituted or unsubstituted)-ammine platinum (II) and then reacting the resulting aqua type product with a corresponding alkali metal salt of bile acid.

REFERENCES:
patent: 4452812 (1984-06-01), Macquet
Tobe and Khokhar, J. Clin. Hematol. and Oncol., vol. 7, #1, pp. 113-133.

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